{"id":120,"date":"2015-09-28T19:58:44","date_gmt":"2015-09-28T19:58:44","guid":{"rendered":"https:\/\/depts.washington.edu\/jaisril\/?page_id=120"},"modified":"2016-09-02T19:17:06","modified_gmt":"2016-09-02T19:17:06","slug":"current-research-questions","status":"publish","type":"page","link":"https:\/\/depts.washington.edu\/jaisril\/research-background\/current-research-questions\/","title":{"rendered":"Current Research Questions"},"content":{"rendered":"<p>Research questions being addressed in the Lingappa lab in 2016 &#8211; 2017:<\/p>\n<ul>\n<li>How does the viral capsid protein HIV-1 Gag find and incorporate the HIV-1 genomes that are packaged during virus assembly?<\/li>\n<\/ul>\n<ul>\n<li>What is the function of cellular enzymes such as ABCE1 and DDX6 that bind to Gag and promote HIV-1 assembly?<\/li>\n<\/ul>\n<ul>\n<li>Can virus evolution in infected hosts select for HIV-1 Gag variants that produce more virus particles?<\/li>\n<\/ul>\n<ul>\n<li>Does the host subvert HIV-1 assembly by recruiting restriction factors to intracellular sites of assembly?<\/li>\n<\/ul>\n<ul>\n<li>Why do\u00a0cellular proteins involved in cancer and neurologic diseases also bind to ABCE1, like HIV-1 Gag?<\/li>\n<\/ul>\n<ul>\n<li>Do other viruses besides retroviruses contain ABCE1 binding sites in their capsid proteins?<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Research questions being addressed in the Lingappa lab in 2016 &#8211; 2017: How does the viral capsid protein HIV-1 Gag find and incorporate the HIV-1 genomes that are packaged during virus assembly? What is the function of cellular enzymes such as ABCE1 and DDX6 that bind to Gag and promote HIV-1 assembly? Can virus evolution&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/jaisril\/research-background\/current-research-questions\/\">Read more<\/a><\/div>\n","protected":false},"author":1,"featured_media":0,"parent":80,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-120","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/pages\/120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/comments?post=120"}],"version-history":[{"count":14,"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/pages\/120\/revisions"}],"predecessor-version":[{"id":485,"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/pages\/120\/revisions\/485"}],"up":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/pages\/80"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/jaisril\/wp-json\/wp\/v2\/media?parent=120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}