{"id":66,"date":"2015-09-25T22:24:12","date_gmt":"2015-09-25T22:24:12","guid":{"rendered":"https:\/\/depts.washington.edu\/jaisril\/?page_id=66"},"modified":"2015-10-07T22:12:44","modified_gmt":"2015-10-07T22:12:44","slug":"publications","status":"publish","type":"page","link":"https:\/\/depts.washington.edu\/jaisril\/publications\/","title":{"rendered":"Jaisri Lingappa\u2019s Publications"},"content":{"rendered":"

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  1. Lingappa, AF, Akintunde, O, Samueli, E, Ewald, C, Michon, M, Ziari, N, Lu, M, Yu, SF, Froehlich, M, Le, PU, Fernandez, Y, Mallesh, S, Lin, J, Kitaygorodskyy, A, Solas, D, Reed, JC, Lingappa, JR, M\u00fcller-Schiffmann, A, Korth, C, Prasad, D, Nalca, A, Aston, E, Fabbri, B, Anand, SK, Campi, TW, Petrouski, E, Dey, D, Andrews, DW, Rubenstein, JL, Lingappa, VR<\/strong>. Small molecule protein assembly modulators with pan-cancer therapeutic efficacy. Open Biol. 2024;14 (12):240210. doi: 10.1098\/rsob.240210<\/a>. PubMed PMID:39689856<\/a> PubMed Central PMC11651915<\/a>.<\/li>\n
  2. Michon, M, M\u00fcller-Schiffmann, A, Lingappa, AF, Yu, SF, Du, L, Deiter, F, Broce, S, Mallesh, S, Crabtree, J, Lingappa, UF, Macieik, A, M\u00fcller, L, Ostermann, PN, Andr\u00e9e, M, Adams, O, Schaal, H, Hogan, RJ, Tripp, RA, Appaiah, U, Anand, SK, Campi, TW, Ford, MJ, Reed, JC, Lin, J, Akintunde, O, Copeland, K, Nichols, C, Petrouski, E, Moreira, AR, Jiang, IT, DeYarman, N, Brown, I, Lau, S, Segal, I, Goldsmith, D, Hong, S, Asundi, V, Briggs, EM, Phyo, NS, Froehlich, M, Onisko, B, Matlack, K, Dey, D, Lingappa, JR, Prasad, DM, Kitaygorodskyy, A, Solas, D, Boushey, H, Greenland, J, Pillai, S, Lo, MK, Montgomery, JM, Spiropoulou, CF, Korth, C, Selvarajah, S, Paulvannan, K, Lingappa, VR<\/strong>. A pan-respiratory antiviral chemotype targeting a transient host multi-protein complex. Open Biol. 2024;14 (6):230363. doi: 10.1098\/rsob.230363<\/a>. PubMed PMID:38889796<\/a> PubMed Central PMC11285769<\/a>.<\/li>\n
  3. Yu, SF, Paulvannan, K, Solas, D, Lingappa, AF, Moreira, AR, Sahu, S, Michon, M, Macieik, A, Goldsmith, D, DeYarman, N, Mallesh, S, Prasad, MD, Maios, C, Ruan, K, Tomassy, GS, Jensen, E, McGuirk, E, Bader, V, Mueller-Schiffmann, A, Reed, JC, Lingappa, JR, Asundi, V, Hong, S, Jacobsen, S, Brandon, N, Ostrow, L, Lloyd, T, Parker, JA, Staats, KA, Ichida, J, Dodge, JC, Dey, D, Korth, C, Selvarajah, S, Lingappa, VR, Rosenfeld, J<\/strong>. Protein Assembly Modulation: A New Approach to Amyotrophic Lateral Sclerosis (ALS) Therapeutics. J Exp Neurol. 2024;5 (4):210-230. doi: 10.33696\/Neurol.5.103<\/a>. PubMed PMID:40977882<\/a> PubMed Central PMC12445735<\/a>.<\/li>\n
  4. Michon, M, M\u00fcller-Schiffmann, A, Lingappa, AF, Yu, SF, Du, L, Deiter, F, Broce, S, Mallesh, S, Crabtree, J, Lingappa, UF, Macieik, A, M\u00fcller, L, Ostermann, PN, Andr\u00e9e, M, Adams, O, Schaal, H, Hogan, RJ, Tripp, RA, Appaiah, U, Anand, SK, Campi, TW, Ford, MJ, Reed, JC, Lin, J, Akintunde, O, Copeland, K, Nichols, C, Petrouski, E, Moreira, AR, Jiang, IT, DeYarman, N, Brown, I, Lau, S, Segal, I, Goldsmith, D, Hong, S, Asundi, V, Briggs, EM, Phyo, NS, Froehlich, M, Onisko, B, Matlack, K, Dey, D, Lingappa, JR, Prasad, MD, Kitaygorodskyy, A, Solas, D, Boushey, H, Greenland, J, Pillai, S, Lo, MK, Montgomery, JM, Spiropoulou, CF, Korth, C, Selvarajah, S, Paulvannan, K, Lingappa, VR<\/strong>. A Pan-Respiratory Antiviral Chemotype Targeting a Host Multi-Protein Complex. bioRxiv. 2023; :. doi: 10.1101\/2021.01.17.426875<\/a>. PubMed PMID:34931190<\/a> PubMed Central PMC8687465<\/a>.<\/li>\n
  5. Lingappa, JR, Lingappa, VR, Reed, JC<\/strong>. Addressing Antiretroviral Drug Resistance with Host-Targeting Drugs-First Steps towards Developing a Host-Targeting HIV-1 Assembly Inhibitor. Viruses. 2021;13 (3):. doi: 10.3390\/v13030451<\/a>. PubMed PMID:33802145<\/a> PubMed Central PMC8001593<\/a>.<\/li>\n
  6. Reed, JC, Solas, D, Kitaygorodskyy, A, Freeman, B, Ressler, DTB, Phuong, DJ, Swain, JV, Matlack, K, Hurt, CR, Lingappa, VR, Lingappa, JR<\/strong>. Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly. J Virol. 2021;95 (3):. doi: 10.1128\/JVI.00883-20<\/a>. PubMed PMID:33148797<\/a> PubMed Central PMC7925099<\/a>.<\/li>\n
  7. Barajas, BC, Tanaka, M, Robinson, BA, Phuong, DJ, Chutiraka, K, Reed, JC, Lingappa, JR<\/strong>. Identifying the assembly intermediate in which Gag first associates with unspliced HIV-1 RNA suggests a novel model for HIV-1 RNA packaging. PLoS Pathog. 2018;14 (4):e1006977. doi: 10.1371\/journal.ppat.1006977<\/a>. PubMed PMID:29664940<\/a> PubMed Central PMC5940231<\/a>.<\/li>\n
  8. Reed, JC, Westergreen, N, Barajas, BC, Ressler, DTB, Phuong, DJ, Swain, JV, Lingappa, VR, Lingappa, JR<\/strong>. Formation of RNA Granule-Derived Capsid Assembly Intermediates Appears To Be Conserved between Human Immunodeficiency Virus Type 1 and the Nonprimate Lentivirus Feline Immunodeficiency Virus. J Virol. 2018;92 (9):. doi: 10.1128\/JVI.01761-17<\/a>. PubMed PMID:29467316<\/a> PubMed Central PMC5899207<\/a>.<\/li>\n
  9. Sette, P, O'Connor, SK, Yerramilli, VS, Dussupt, V, Nagashima, K, Chutiraka, K, Lingappa, J, Scarlata, S, Bouamr, F<\/strong>. HIV-1 Nucleocapsid Mimics the Membrane Adaptor Syntenin PDZ to Gain Access to ESCRTs and Promote Virus Budding. Cell Host Microbe. 2016;19 (3):336-48. doi: 10.1016\/j.chom.2016.02.004<\/a>. PubMed PMID:26962944<\/a> PubMed Central PMC4804359<\/a>.<\/li>\n
  10. Tanaka, M, Robinson, BA, Chutiraka, K, Geary, CD, Reed, JC, Lingappa, JR<\/strong>. Mutations of Conserved Residues in the Major Homology Region Arrest Assembling HIV-1 Gag as a Membrane-Targeted Intermediate Containing Genomic RNA and Cellular Proteins. J Virol. 2016;90 (4):1944-63. doi: 10.1128\/JVI.02698-15<\/a>. PubMed PMID:26656702<\/a> PubMed Central PMC4734008<\/a>.<\/li>\n
  11. Lingappa, JR, Reed, JC, Tanaka, M, Chutiraka, K, Robinson, BA<\/strong>. How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle. Virus Res. 2014;193 :89-107. doi: 10.1016\/j.virusres.2014.07.001<\/a>. PubMed PMID:25066606<\/a> PubMed Central PMC4351045<\/a>.<\/li>\n
  12. Robinson, BA, Reed, JC, Geary, CD, Swain, JV, Lingappa, JR<\/strong>. A temporospatial map that defines specific steps at which critical surfaces in the Gag MA and CA domains act during immature HIV-1 capsid assembly in cells. J Virol. 2014;88 (10):5718-41. doi: 10.1128\/JVI.03609-13<\/a>. PubMed PMID:24623418<\/a> PubMed Central PMC4019110<\/a>.<\/li>\n
  13. Lingappa, JR, Zigmond, RE<\/strong>. Limited recovery of pineal function after regeneration of preganglionic sympathetic axons: evidence for loss of ganglionic synaptic specificity. J Neurosci. 2013;33 (11):4867-74. doi: 10.1523\/JNEUROSCI.3829-12.2013<\/a>. PubMed PMID:23486957<\/a> PubMed Central PMC3640627<\/a>.<\/li>\n
  14. Lingappa, UF, Wu, X, Macieik, A, Yu, SF, Atuegbu, A, Corpuz, M, Francis, J, Nichols, C, Calayag, A, Shi, H, Ellison, JA, Harrell, EK, Asundi, V, Lingappa, JR, Prasad, MD, Lipkin, WI, Dey, D, Hurt, CR, Lingappa, VR, Hansen, WJ, Rupprecht, CE<\/strong>. Host-rabies virus protein-protein interactions as druggable antiviral targets. Proc Natl Acad Sci U S A. 2013;110 (10):E861-8. doi: 10.1073\/pnas.1210198110<\/a>. PubMed PMID:23404707<\/a> PubMed Central PMC3593902<\/a>.<\/li>\n
  15. Reed, JC, Molter, B, Geary, CD, McNevin, J, McElrath, J, Giri, S, Klein, KC, Lingappa, JR<\/strong>. HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly. J Cell Biol. 2012;198 (3):439-56. doi: 10.1083\/jcb.201111012<\/a>. PubMed PMID:22851315<\/a> PubMed Central PMC3413349<\/a>.<\/li>\n
  16. Klein, KC, Reed, JC, Tanaka, M, Nguyen, VT, Giri, S, Lingappa, JR<\/strong>. HIV Gag-leucine zipper chimeras form ABCE1-containing intermediates and RNase-resistant immature capsids similar to those formed by wild-type HIV-1 Gag. J Virol. 2011;85 (14):7419-35. doi: 10.1128\/JVI.00288-11<\/a>. PubMed PMID:21543480<\/a> PubMed Central PMC3126549<\/a>.<\/li>\n
  17. Okeoma, CM, Huegel, AL, Lingappa, J, Feldman, MD, Ross, SR<\/strong>. APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions. Cell Host Microbe. 2010;8 (6):534-43. doi: 10.1016\/j.chom.2010.11.003<\/a>. PubMed PMID:21147467<\/a> PubMed Central PMC3023938<\/a>.<\/li>\n
  18. Thielen, BK, McNevin, JP, McElrath, MJ, Hunt, BV, Klein, KC, Lingappa, JR<\/strong>. Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms. J Biol Chem. 2010;285 (36):27753-66. doi: 10.1074\/jbc.M110.102822<\/a>. PubMed PMID:20615867<\/a> PubMed Central PMC2934643<\/a>.<\/li>\n
  19. Lingappa, JR, Thielen, BK<\/strong>. Assembly of immature HIV-1 capsids using a cell-free system. Methods Mol Biol. 2009;485 :185-95. doi: 10.1007\/978-1-59745-170-3_13<\/a>. PubMed PMID:19020826<\/a> PubMed Central PMC2678559<\/a>.<\/li>\n
  20. Klein, KC, Reed, JC, Lingappa, JR<\/strong>. Intracellular destinies: degradation, targeting, assembly, and endocytosis of HIV Gag. AIDS Rev. 2007;9 (3):150-61. . PubMed PMID:17982940<\/a> .<\/li>\n
  21. Thielen, BK, Klein, KC, Walker, LW, Rieck, M, Buckner, JH, Tomblingson, GW, Lingappa, JR<\/strong>. T cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activity. PLoS Pathog. 2007;3 (9):1320-34. doi: 10.1371\/journal.ppat.0030135<\/a>. PubMed PMID:17892323<\/a> PubMed Central PMC1993843<\/a>.<\/li>\n
  22. Dooher, JE, Schneider, BL, Reed, JC, Lingappa, JR<\/strong>. Host ABCE1 is at plasma membrane HIV assembly sites and its dissociation from Gag is linked to subsequent events of virus production. Traffic. 2007;8 (3):195-211. doi: 10.1111\/j.1600-0854.2006.00524.x<\/a>. PubMed PMID:17233757<\/a> PubMed Central PMC1865004<\/a>.<\/li>\n
  23. Lingappa, JR, Dooher, JE, Newman, MA, Kiser, PK, Klein, KC<\/strong>. Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly. J Biol Chem. 2006;281 (7):3773-84. doi: 10.1074\/jbc.M507255200<\/a>. PubMed PMID:16275648<\/a> .<\/li>\n
  24. Lingappa, VR, Lingappa, JR<\/strong>. Recent insights into biological regulation from cell-free protein-synthesizing systems. Mt Sinai J Med. 2005;72 (3):141-60. . PubMed PMID:15915309<\/a> .<\/li>\n
  25. Klein, KC, Dellos, SR, Lingappa, JR<\/strong>. Identification of residues in the hepatitis C virus core protein that are critical for capsid assembly in a cell-free system. J Virol. 2005;79 (11):6814-26. doi: 10.1128\/JVI.79.11.6814-6826.2005<\/a>. PubMed PMID:15890921<\/a> PubMed Central PMC1112097<\/a>.<\/li>\n
  26. Lingappa, JR, Newman, MA, Klein, KC, Dooher, JE<\/strong>. Comparing capsid assembly of primate lentiviruses and hepatitis B virus using cell-free systems. Virology. 2005;333 (1):114-23. doi: 10.1016\/j.virol.2004.12.024<\/a>. PubMed PMID:15708597<\/a> .<\/li>\n
  27. Newman, EN, Holmes, RK, Craig, HM, Klein, KC, Lingappa, JR, Malim, MH, Sheehy, AM<\/strong>. Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity. Curr Biol. 2005;15 (2):166-70. doi: 10.1016\/j.cub.2004.12.068<\/a>. PubMed PMID:15668174<\/a> .<\/li>\n
  28. Dooher, JE, Lingappa, JR<\/strong>. Cell-free systems for capsid assembly of primate lentiviruses from three different lineages. J Med Primatol. 2004;33 (5-6):272-80. doi: 10.1111\/j.1600-0684.2004.00075.x<\/a>. PubMed PMID:15525328<\/a> .<\/li>\n
  29. Dooher, JE, Pineda, MJ, Overbaugh, J, Lingappa, JR<\/strong>. Characterization of virus infectivity and cell-free capsid assembly of SIVMneCL8. J Med Primatol. 2004;33 (5-6):262-71. doi: 10.1111\/j.1600-0684.2004.00074.x<\/a>. PubMed PMID:15525327<\/a> .<\/li>\n
  30. Klein, KC, Polyak, SJ, Lingappa, JR<\/strong>. Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly. J Virol. 2004;78 (17):9257-69. doi: 10.1128\/JVI.78.17.9257-9269.2004<\/a>. PubMed PMID:15308720<\/a> PubMed Central PMC506955<\/a>.<\/li>\n
  31. Dooher, JE, Lingappa, JR<\/strong>. Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells. J Virol. 2004;78 (4):1645-56. doi: 10.1128\/jvi.78.4.1645-1656.2004<\/a>. PubMed PMID:14747530<\/a> PubMed Central PMC369511<\/a>.<\/li>\n
  32. Zimmerman, C, Klein, KC, Kiser, PK, Singh, AR, Firestein, BL, Riba, SC, Lingappa, JR<\/strong>. Identification of a host protein essential for assembly of immature HIV-1 capsids. Nature. 2002;415 (6867):88-92. doi: 10.1038\/415088a<\/a>. PubMed PMID:11780123<\/a> .<\/li>\n
  33. Singh, AR, Hill, RL, Lingappa, JR<\/strong>. Effect of mutations in Gag on assembly of immature human immunodeficiency virus type 1 capsids in a cell-free system. Virology. 2001;279 (1):257-70. doi: 10.1006\/viro.2000.0706<\/a>. PubMed PMID:11145907<\/a> .<\/li>\n
  34. Lingappa, JR, Hill, RL, Wong, ML, Hegde, RS<\/strong>. A multistep, ATP-dependent pathway for assembly of human immunodeficiency virus capsids in a cell-free system. J Cell Biol. 1997;136 (3):567-81. doi: 10.1083\/jcb.136.3.567<\/a>. PubMed PMID:9024688<\/a> PubMed Central PMC2134302<\/a>.<\/li>\n
  35. Lingappa, JR, Martin, RL, Wong, ML, Ganem, D, Welch, WJ, Lingappa, VR<\/strong>. A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle. J Cell Biol. 1994;125 (1):99-111. doi: 10.1083\/jcb.125.1.99<\/a>. PubMed PMID:7908022<\/a> PubMed Central PMC2120005<\/a>.<\/li>\n
  36. Lingappa, JR, Zigmond, RE<\/strong>. Pineal transplants in oculo: limitations on the ability of collateral sprouts of foreign neurons to establish normal function. J Neurosci. 1987;7 (11):3525-8. doi: 10.1523\/JNEUROSCI.07-11-03525.1987<\/a>. PubMed PMID:3681404<\/a> PubMed Central PMC6569029<\/a>.<\/li>\n
  37. Lingappa, JR, Zigmond, RE<\/strong>. A histochemical study of the adrenergic innervation of the rat pineal gland: evidence for overlap of the innervation from the two superior cervical ganglia and for sprouting following unilateral denervation. Neuroscience. 1987;21 (3):893-902. doi: 10.1016\/0306-4522(87)90045-5<\/a>. PubMed PMID:3627441<\/a> .<\/li>\n
  38. Lingappa, VR, Lingappa, JR, Blobel, G<\/strong>. Signal sequences for early events in protein secretion and membrane assembly. Ann N Y Acad Sci. 1980;343 :356-61. doi: 10.1111\/j.1749-6632.1980.tb47264.x<\/a>. PubMed PMID:6994554<\/a> .<\/li>\n
  39. Lingappa, VR, Lingappa, JR, Blobel, G<\/strong>. Chicken ovalbumin contains an internal signal sequence. Nature. 1979;281 (5727):117-21. doi: 10.1038\/281117a0<\/a>. PubMed PMID:471058<\/a> .<\/li>\n
  40. Lingappa, VR, Lingappa, JR, Prasad, R, Ebner, KE, Blobel, G<\/strong>. Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein. Proc Natl Acad Sci U S A. 1978;75 (5):2338-42. doi: 10.1073\/pnas.75.5.2338<\/a>. PubMed PMID:276877<\/a> PubMed Central PMC392548<\/a>.<\/li>\n
  41. Polyak SJ, Klein KC, Shoji I, Miyamura T, Lingappa JR<\/strong>. Assemble and Interact: Pleiotropic Functions of the HCV Core Protein. In: Tan SL, editor. SourceHepatitis C Viruses: Genomes and Molecular Biology. Norfolk (UK): Horizon Bioscience; 2006. Chapter 3. PubMed PMID:21250388<\/a><\/ol>\n

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