Elizabeth Speltz

Elizabeth Speltz
Bagley Hall 411
(206) 685-2431
espeltz at uw
  • WRF Innovation Postdoctoral Fellow ¦ 
Department of Chemistry ¦ 
University of Washington

Betsy is engineering scaffold proteins to study structure-function relationships in scaffolded signaling protein reactions.

Education: 

Ph.D. ¦ 
Molecular Biophysics and Biochemistry ¦ 
Yale University ¦ 
Advisor: Lynne Regan ¦ 

Awards: 

NSF Graduate Research Fellowship ¦ 
2012-2015
WRF Innovation Fellowship - Institute for Protein Design ¦ 
2016

Publications: 

Speltz, E.B., Sawyer, N., and Regan, L. (2016) Combining design and selection to create novel protein-peptide interactions. Methods Enzymol. 580, 203-222
http://www.ncbi.nlm.nih.gov/pubmed/27586335

Pratt, S., Speltz, E.B., Mochrie, S., and Regan, L. (2016) Designed proteins as novel imaging reagents in living E. coli. Chembiochem. 17, 1652-1657
http://www.ncbi.nlm.nih.gov/pubmed/27304706

Speltz, E.B., Brown, R.S., Hajare, H., Schlieker, C., Regan, L. (2015) Designed repeat protein modules as protein purification affinity reagents. Biochem. Soc. Trans. 43, 874-880
http://www.ncbi.nlm.nih.gov/pubmed/26517897

Speltz, E.B., Nathan, A., and Regan, L. (2015) Design of protein-peptide interaction modules for assembling supramolecular structures in vivo and in vitro. ACS Chem. Biol. 10, 2108-2115.
http://www.ncbi.nlm.nih.gov/pubmed/26131725

Speltz, E.B. and Regan, L. (2013) White and green screening with circular polymerase extension cloning for easy and reliable cloning. Prot. Sci. 22, 859-864.
http://www.ncbi.nlm.nih.gov/pubmed/23592493

Sawyer, N.A.*, Speltz, E.B.*, and Regan, L (2013) NextGen protein design. Biochem. Soc. Trans. 41, 1131-1136.
http://www.ncbi.nlm.nih.gov/pubmed/24059497