Welcome to Lidstrom Laboratory
Research in Dr. Lidstrom's laboratory is focused on molecular
and metabolic manipulations of methylotrophic bacteria, which
are capable of growth on methane, methanol, and methylated amines.
The long-term goal of this research is to develop environmentally
sound and economically viable alternatives to current chemical
production and cleanup strategies. Genetic, physiological and
metabolic modeling approaches are used to understand key metabolic
pathways in these bacteria, with the goal of directed manipulation
of key metabolic pathways and enzymes. The laboratory's recent
discovery that methylotrophic bacteria contain a metabolic pathway
previously thought to be found only in methanogenic archaea
has generated a new research thrust focused on evolution of
C1 metabolic pathways across the bacterial/archaeal boundaries.
These studies are now being augmented by genomic approaches,
including proteomics and expression microarrays.
Fax: (206) 616-5721