Wang Wang, MD, PhD

  • Researcher, Mitochondria and Metabolism Center
  • Assistant Professor, Anesthesiology and Pain Medicine
  • Adjunct Assistant Professor of Pathology

Research

  • Cardiovascular Bioengergetics and Mitochondrial Function Regulation
  • Metabolic Pathways and Therapeutic Targets in Heart Failure
  • Mitochondrial Dysfunction in Neurodegenerative Disease
  • Confocal Imaging and In Vivo Evaluation of Mitochondrial Function

Awards

  • National Institutes of Health, Fellow Award for Research Excellence (2003 & 2004)
  • International Society for Heart Research (ISHR), Richard J. Bing Award for Young Investigators (2007)
  • The Academy of Cardiovascular Research Excellence (ACRE) Young Investigator Award (2011)

Current Memberships

  • American Heart Association
  • American Physiological Society
  • American Society for Biochemistry and Molecular Biology
  • Biophysical Society
  • International Society for Heart Research

Current Funding

  • American Heart Association Scientist Develpment Grant: Activation and Role of Mitochondrial Permeability Transition Pore in Cardiac Exitation Contraction Coupling.
  • National Institutes of Health (R01, PI: Tian, Rong): Complex I Deficiency Triggered Acceleration of Heart Failure.
  • National Institutes of Health (R01, PI: Wang Wang): Mitochondrial Respiration and Superoxide Production in Healthy and Failing Hearts.

Selected Publications

  • Georgios Karamanlidis, Chi Fung Lee, Lorena Garcia-Menendez, Stephen C. Kolwicz, Jr., Wichit Suthammarak, Guohua Gong, Margaret M. Sedensky, Philip G. Morgan, Wang Wang, and Rong Tian. Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metab. 18, 239-250, 2013.
  • Guohua Gong, Wang Wang. Confocal Imaging of Single Mitochondrial Superoxide Flashes in Intact Heart and in vivo. J. Vis. Exp. e50818, 2013.
  • Lan Wei-LaPierre, Guohua Gong, Brent J. Gerstner, Sylvie Ducreux, David I. Yule, Sandrine Pouvreau, Xianhua Wang, Shey-Shing Sheu, Heping Cheng, Robert T. Dirksen, Wang Wang. Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity. J. Biol. Chem. 288, 10567-10577, 2013.
  • Wang Wang, Matthew S. Barnabei, Michelle Asp, Frazer Heinis, Erik Arden, Jennifer Davis, Elizabeth Braunlin, Qi Li, Johathan Davis, James D. Potter, Joseph M. Metzger. Noncanonical EF-hand Motif Strategically Delays Ca2+ Buffering to Enhance Cardiac Performance.Nat.Med.In press. 2013.
  • Wang Wang*, Huaqiang Fang, Linda Groom, Aiwu Cheng, Wanrui Zhang, Jie Liu, Xianhua Wang, Kaitao Li, Peidong Han, Ming Zheng, Jinhu Yin, Weidong Wang, Mark P. Mattson, Joseph P. Y. Kao, Edward G. Lakatta, Shey-Shing Sheu, Kunfu Ouyang, Ju Chen, Robert T. Dirksen, Heping Cheng*. Superoxide flashes in single mitochondria. Cell. 134, 279-290, 2008. (*: corresponding authors)

Wang Lab

Contact Information

Mitochondria and Metabolism Center
850 Republican St, Room N121
Seattle, WA  98109-8057
Phone: 206-685-4765
Fax: 206-616-4819
Email: Wang Wang