Research Overview

The Mitochondria and Metabolism Center supports a broad range of research, including basic science and translational research. Besides providing an anchor for interactions among the multi-disciplinary researchers in this field, the center also offers two technology platforms: NMR spectroscopy and imaging, and metabolomics, in collaboration with Radiology, Chemistry and the Institute of Translational Health Sciences (ITHS) at the University of Washington. Below are areas of active research among MMC investigators and affiliated faculty and links for further information.


Mitochondrial function and reactive oxygen species

Research on the regulation of mitochondrial function and ROS metabolism, and the role of mitochondria in biology and pathogenesis of human diseases.

Cell metabolism and signaling

Research on the regulation of cell metabolism and signaling mechanisms.


Novel approaches to understand bioenergetics in vivo and to investigate the role of deranged bioenergetics in the development of diseases.


Utilize metabolomics approaches to dissect mammalian biology and to apply the technology to clinical research.

Mitochondrial function and model organisms

Take advantage of the well-defined genetics to study biology of mitochondria and to identify key regulators of mitochondrial function.

Inborn mitochondrial diseases

Study primary mitochondria and metabolic diseases caused by mutations of mitochondrial and nuclear genes.

Translational research

Develop novel diagnostic and therapeutic strategies based on mitochondrial biology and metabolic disciplines.