Department of Neurology

Selected Publications

A. McDonough & J. R. Weinstein. Role of Microglia in Ischemic Preconditioning. Glia (2019), 1-18,

McDonough, S. Noor, R.V. Lee, R. Dodge III, J.S. Strosnider, J. Shen, S. Davidson, T. T. Möller, G.A. Garden and J. R. Weinstein. Ischemic Preconditioning Induces Cortical Microglial Proliferation and a Transcriptomic Program of Robust Cell Cycle Activation. Glia (2019), 1-19,

McDonough, R.V. Lee, S. Noor, C. Lee, T. Le, M. Iorga, J.L.H. Phillips, S. Murphy, T. Möller and J.R. Weinstein. Ischemia/Reperfusion Induces Interferon Stimulated Gene Expression in Microglia. Journal of Neuroscience (2017), 37(34): 8292-8308, PMID 28747383.

A. McDonough, R.V. Lee and J.R. Weinstein. Microglial Interferon Signaling and White Matter. Neurochemical Research, (2017), 42(9), 2625-38, PMID 28540600

R.G.W. Staal, J.R. Weinstein, M. Nattini, M. Cajina, G. Chandresana and T. Möller. Senicapoc: Repurposing a drug to target microglia KCa3.1 in stroke. Neurochemical Research, (2017), 42: 2639-45

A. McDonough and J.R. Weinstein. Neuroimmune Response in Ischemic Preconditioning. Neurotherapeutics, (2016), 13(4): 748-761. PMID: 27525700

M.A. Hamner, Z. Ye, R.V. Lee, J.R. Colman, T. Le, D.C. Gong, B.R. Ransom and J. R. Weinstein. Ischemic Preconditioning in White Matter: Magnitude and Mechanism. Journal of Neuroscience (2015) 25:35 (47): 15599-611. PMID: 26609155

J.R. Weinstein*, Y. Quan*, J.F. Hanson, L. Colonna, M. Iorga, S. Honda, K. Shibuya, A. Shibuya, K.B. Elkon and T. Möller. IgM-Dependent Phagocytosis in Microglia is Mediated by Complement Receptor 3, not Fc/ Receptor. Journal of Immunology (2015), 1:195(11): 5309-17. PMID: 26500348; *equal contribution

K.J. Becker, R.V. Lee, J. Schulze, D. Zierath, P. Tanzi, K. Cain, A. Dressel, D. Shibata, and J.R. Weinstein. Post-Stroke Fatigue: Hints to a Biological Mechanism. Journal of Stroke and Cerebrovascular Diseases (2015), 24(3): 618. PMID: 25542762.

W. Su, S. Hopkins, N.K. Nesser, B. Sopher, A. Silvestroni , S. Ammanuel, S. Jayadev, T. Möller, J.R. Weinstein and G.A. Garden. The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf. Journal of Immunology (2014) 192(1): 358-66. PMID: 24319262. PMCID: PMC4195583.

J.R. Weinstein, J. Schulze, R.V. Lee, P. Tanzi, D. Zierath, K. Cain, P. Mitchell, R. Cohen and K.J. Becker. Functional Polymorphisms in Toll-like Receptor 4 are Associated with Worse Outcome in Acute Ischemic Stroke Patients. NeuroReport (2014) 28; 25(8): 580-4. PMID: 24784586. PMCID: PMC4009512.

K.J. Becker, D. Dankwa, R.V. Lee, J. Schulze, D. Zierath, P. Tanzi, K. Cain, A. Dressel, D. Shibata, and J.R. Weinstein. Stroke, IL-1ra, IL1RN, Infection and Outcome. Neurocritical Care (2013), 21(1): 140-6. PMID: 24233813. PMCID: PMC4161032.

J.R. Weinstein, I.P. Koerner and T.Möller. Microglia in Cerebral Ischemia. Future Neurology, (2010), 5(2): 227-246. PMID: 20401171. PMCID: PMC2853969.

Y. Quan, T. Möller and J.R. Weinstein. Regulation of Fcgamma Receptors and Immunoglobulin G-mediated Phagocytosis in Mouse Microglia. Neuroscience Letters (2009), 16:464(1):29-33. PMID: 19679164; PubMed Central PMCID: PMC2747046.

C.J. Creutzfeldt*, J.R. Weinstein*, K.J. Becker, W.T. Longstreth, T.O. McPharlin and D.L.Tirschwell. Prior Antiplatelet Therapy, Platelet Infusion Therapy, and Outcome after Intracerebral Hemorrhage. Journal of Stroke and Cerebrovascular Diseases (2009), 18(3): 221-228. PMID: 19426894. PMCID: PMC2830090. *equal contribution

J.R. Weinstein, M. Zhang, M. Kutlubaev, R. Lee, C. Bishop, H. Andersen, U. Hanisch and T. Möller. Thrombin-induced regulation of CD95 (Fas) expression in the N9 microglial cell line: Evidence for involvement of proteinase-activated receptor1 and extracellular signal-regulated kinase 1/2. Neurochemical Research (2009), 34:445-452. PMID: 18686031.

J.R. Weinstein, Sarah Swarts, Caroline Bishop, Uwe-Karsten Hanisch and Thomas Möller. Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors. Glia (2008), 56:16-26. PMID: 17910052. PMCID: PMC2926344.

J.R. Weinstein, S. Hong, J.D. Kulman, C. Bishop, J. Kuniyoshi, H. Andersen, B.R. Ransom, U. Hanisch and T. Möller. Unraveling Thrombin’s true microglia-activating potential: Markedly disparate profiles of pharmaceutical-grade and Commercial-grade thrombin preparations. Journal of Neurochemistry (2005), 95: 1177-87. PMID: 16271051.

S. Balcaitis, J.R. Weinstein, S. Li, J. Chamberlain and T. Möller. Expression of proteolytically activated receptors in mouse microglial cells. Glia (2005), 50: 48-55. PMID: 15625717.

J.R. Weinstein, A.L. Lau, L.F. Brass and D.D. Cunningham. Injury related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line. Journal of Neurochemistry (1998), 71(3): 1034-1050. PMID: 9721728.

J.R. Weinstein, S.J. Gold, D.D. Cunningham and C.M. Gall. Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and co-distribution with prothrombin mRNA. Journal of Neuroscience (1995), 15(4): 2906-2919. PMID: 7722637.

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