Neal-Perry Genevieve

Genevieve S Neal-Perry, MD, PhD

Professor
Division Director, Reproductive Endocrinology and Infertility

 
Joined UW Medicine:

1/16/15

Clinical Focus:

Reproductive Endocrinology and Infertility:
• Infertility and fertility-sparing therapy
• Oncofertility
• Ovarian disorders causing infertility
• Menstrual cycle dysfunction or early menopause
• Disorders of menses
• Disorders of pituitary or hypothalamus affecting reproduction
• Recurrent pregnancy loss
• Menopause
• Disorders of puberty
• Surgical management of uterine polyps
• Uterine scar tissue

Licensure:

Washington, 2014

Certification:

• Obstetrics and Gynecology, 2005
• Reproductive Endocrinology and Infertility, 2009

Education:

• MD Degree/PhD, Pharmacology
   (Joint Program: Robert Wood Johnson Medical School, Rutgers University, 1998)
• Residency in Obstetrics and Gynecology
   (Beth Israel Medical Center, 2002)
• Fellowship in Reproductive Endocrinology and Infertility
   (Albert Einstein College of Medicine, 2005)

Research Interests:

• Effect of nutrition, environment and age on fertility in women and men.
• Menopause and the perimenopause
• Oncofertility and onco-reproductive health

Memberships:

• American Aging Association
• American Board of Obstertrics and Gynecology
• American College of Obstertrics and Gynecology
• American Society for Reproductive Medicine
• The Endocrine Society
• National Medical Association
• Society for Neuroscience
• Society for Reproduction, Endocrinology and Infertility
• The Society for Neuroscience
• Society for the Study of Reproduction
• Women in Endocrinology

Honors:

• Merck Senior Fellow Award: The Endocrine Society, 2005
• Carl Storm Fellowship for Reproductive Tract Biology Gordon Conference, 2006
• American Federation for Aging Research Award, 2006-2008
• RWJF Harold Amos Faculty Development Award, 2005-2009
• Contraceptive and Infertility NIH Loan Repayment Program Recipient, 2005-2009
• AAOGF Bay Jacobs Faculty Travel Award for AGOS, 2008
• Faculty of 1000 Biology review in recognition of important scientific contribution to the physiology of reproductive aging and neuroendocrinology, 2009
• Zondek Grant for Female Reproductive Research, 2009-2010
• Society For Neuroscience Scholars Program, 2011
• AMA Women Physicians Section Physician Mentor Award, 2013
• Endocrine Society Young Investigator Mentor Award, 2014
• Recognized by Faculty of 1000 as an important scientific contributor to the field of diabetes and Endocrinology, 2016
National Leadership Roles:
• Endocrine Society Council Member at Large
• The American Board of Obstetrics and Gynecology- Reproductive Endocrinology and Infertility Board Member

Selected Publications:

• Dicken C, Israel D, Shu J, Neal-Perry G Prepubertal vitamin D3 deficiency reversibly disrupts the pubertal transition and the establishment of regular estrous cycles. Biology of Reproduction, 2012, 30;87(2):51
• Dowling NM, Gleason CE, Manson JE, Hodis HN, Miller VM, Brinton EA, Neal-Perry G, Santoro MN, Cedars M, Lobo R, Merriam GR, Wharton W, Naftolin F, Taylor H, Harman SM, Asthana S. Characterization of vascular disease risk in postmenopausal women and its association with cognitive performance. PLoS One. 2013; 8(7):e68741
• Sheffer-Babila S, Sun Y, Israel D, Liu S, Neal-Perry G, Chua S, Agouti-Related Peptide Plays a Critical Role in Leptin's Effects on Puberty and Reproduction. American Journal of Physiology Endocrinology Metabolism 2013; 305(12):E1512-20
• Kaufman A, Sun Y, Shu J, Neal-Perry G.  Intracerebroventricular vasointestinal peptide rescues the LH surge in middle-aged females by activation of the kisspeptinergic neurotransmitter pathway. Endocrinology 2014; 2222-32
• Neal-Perry G, Yao D, Sun Y, Etgen A., Insulin-like Growth Factor 1 modulates glutamatergic and kisspeptinergic neurotransmission in ovarian steroid primed females. Endocrinology 2014; 155(5)1827-37
• Kudesia R, Neal-Perry GS. Menopausal implications of polycystic ovarian syndrome. Seminars in Reproductive Medicine 2014; May;32(3):222-9.
• Harman M, Black D, Naftolin F, Brinton E., Budoff M., Cedars M., Hopkins PN, Lobo R., Manson J, Merriam G, Miller V, Neal-Perry G, Santoro N, Taylor H, Yan M, Hodis H., Arterial Imaging Outcomes and Cardiovascular Risk Factors in Recently Menopausal Women in The Kronos Early Estrogen Prevention Study (KEEPS): A Randomized Controlled Trial. Annals of Internal Medicine. 2014; 161(4):249-60
• Gleason CE, Dowling NM, Wharton W, Manson JE, Miller VM, Atwood CS, Brinton EA, Cedars MI, Lobo RA, Merriam GR, Neal-Perry G, Santoro NF, Taylor HS, Black DM, Budoff MJ, Hodis HN, Naftolin F, Harman SM, Asthana S. Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study. PLoS Medicine 2015;12(6):e1001833
• Thornton K and Neal-Perry G. Menopause and Sexuality, Endocrinology Metabolism Clinics of North America, 2015; 44(3):649-61.
• Nicholas C, Davis J, Fisher T, Segal T, Petti M, Sun Y, Wolfe A, Neal-Perry G. Maternal Vitamin D Deficiency Programs Reproductive Dysfunction in Female Mice Offspring through Adverse Effects on the Neuroendocrine Axis. Endocrinology. 2016 Jan 7:en20151638. [Epub ahead of print] PMID: 26741195
• Pavlović J, Allshouse A, Santoro NF, Crawford S. Thurston R, Neal-Perry G, Lipton R, Derby C,  Sex hormones in women with and without migraine: Evidence of migraine specific hormone profiles, Accepted Neurology 2016
• Kankare J, Neal GS, Salminen T, GlumhoffT, Cooperman BS, and Lahti R, and Goldman A The structure of E. coli inorganic pyrophosphatase at 2.7°A resolution. Protein Engineering 7(7): 823-830.
• Santoro N, Isaac B, Neal-Perry G, Tovaghol A, Weingart L, Nussbaum A, Thalkur S, Jinnai  H, Khosla N, Barad D Impaired folliculogenesis and ovulation in older reproductive aged women. The Journal of Clinical Endocrinology and Metabolism 88(11): 5502-5509
• Neal-Perry GS, Zeevalk, GD, Santoro, NF, EtgenAM Attenuation of preoptic area glutamate  release correlates with reduced luteinizing hormone secretion in middle-aged female Rats. Endocrinology  146(10): 4331-4339
• Neal-'Perry GS, Zeevalk GD, Shu J, Etgen AM Restoration of the LH surge in middle­ aged rats by altering the balance of GABA and glutamate transmission in the medial preoptic area. Biology of Reproduction 79(5): 878-888
• Neal-Perry G, Lebesgue Dt, Lederman M*, Shu J, Zeevalk GD, Etge:p.AM The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area. Endocrinology 150(8): 3699-3708
• Lederman  M*, Lebesgue D; Gonzalezvau, Shu J, Merhi ZO*, EtgenAM, Neal-Perry G Age-related LH surge dysfunction correlates with reduced responsiveness of hypothalamic anteroventral periventricular  nucleus kisspeptin neurons to estradiol positive feedback in middle;..aged rats. Neuropharmacology 58(1): 314-320
• Erkan B*, Nejat E*, and Neal-Perry G Determinants of female reproductive senescence: differential roles for the ovary and the neuroendocrine rutis. Seminars in Reproductive Medicine. 28(5):370-379
• Buyuk, E* and Neal-Perry GS Translational research and reproductive senescence. The Female Patient 34(12): 23-25
• Todd BJ:Ft, Merhi ZO:J:*, Shu j, EtgenAM, Neal-Perry GS Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: implications for female reproductive aging. Endocrinology 151(3): 1356.:.66
• Chtiang M*, ZapantisA, Taylor M, Jindal SK, Neal-Perry GS Lieman HJ, Polotsky A, Prolonged gona<iotropin stimulation is associated with decreased ART success. Journal of Assistant Reproductive Genetic 27(12):711-7
• Sun Yt, Todd BJt, Thornton  KR, Etgen AM and Neal-Perry G. Differential Effects of Hypothalamic Insulin-Like Growth Factor-1 Receptors on Gonadotropin Releasing Hormone Neuronal Activation during Steroid-Induced LH Surges in Young and Middle­ Aged Female Rats. Endocrinology 152(11):4276-87
• Karmon AR, Hailpern S, Neal-Perry G Green R, Santoro N, and Polotsky A. Association of Ethnicity with a Diagnosis of Infertility, Involuntary Childlessness and Perceived Reasons for Infertility. Fertility and Sterility Nov;g6(5):1200-5
• Neal-Perry G,  Nejat E*, and Dicken C* The neuroendocrine physiology of female reproductive aging: An Update.  2010; Maturitas 67(1):34-8
• McAvey B* and Neal-Perry G, Evaluating and treating insomnia in menopausal women. 2010; Menopausal Medicine 18(3): S1-S7.
• Neal-Perry G. Menopausal Symptoms:  Therapeutic Options and Special Considerations. Sexuality, Reproduction and Menopause 10(1):s23-S24.
• Neal-Perry G and PalL Estrogen for Perimenopause and Early Menopause. 2011 Contemporary Obstetrics and Gynecology
• Luk J, Torrealday S, Neal-Perry G and PalL Relevance of vitamin Din reproduction. Human Reproduction. 2012; Oct:27(10):3015-27
• Sun Yt, Shu J, and Kyei Kau, Neal-Perry G, Intracerebroventricular Infusion of Vasoactive Intestinal  Peptide (VIP) Rescues the Luteinizing Hormone Surge in Middle­ Aged Female Rats. Frontiers in Endocrinology 3: 24-33.
• Santollo Jt, Yao D, Neal-Perry G and Etgen M, Middle-aged female rats retain sensitivity to the anorexigenic effect of exogenous estradiol.  Behavior Brain Research 2012 Apr 12;232(1):159-164
• Dicken C*, Israel Dtu, Davis J*, Shu J, Neal-Perry G Prepubertal vitamin D3 deficiency reversibly disrupts the pubertal transition and the establishment of regular estrous cycles.
• Asemota OAu*, Girda Er, Duenas Or, Neal-Perry G,. Pollack SE Actinomycosis pelvic abscess after in vitro fertilizatimi. Fertil Steril. 2013 May 14. pii: SOOlS-0282(13)00514-1. Bioi Reprod  30;87(2):51.
• Dowling NM, Gleason CE, Manson  JE, Hodis HN, Miller VM, Brinton  EA, Neal-Perry G, Santoro MN, Cedars M, Lobo R, Merriam  GR, Wharton W, Naftolin F, Taylor H, Harman SM, Asthana  S. Characterization of vascular disease risk in postmenopausal women and its association with cognitive performance. PLoS One. 2013; Jul 17;8(7):e68741
• Sheffer-Babila S*, Sun Yt, Israel Dtu,  Liu S, Neal-Perry G, Chua S, Agouti-Related Peptide-Plays a Critical Role in Leptin's  Effects on Puberty and Reproduction. American Journal of Physiology Endocrinology Metabolism. 2013 Oct 29. [Epub  ahead of print]
• Kaufman A, Sun Yt, Shu J, Neal-Perry G.  lntracerebrove:ritricular vasointestinal peptide rescues  the LH surge in middle-aged females by activation of the kisspeptinergic neurotransmitter pathway. Endocrinology (2014) 22·22-32; doi:10.1210jen 2013-1793,  . PMID 24654782.
• Neal-Perry G., Yao D., Sun Yt., EtgenA., Insulin-like Growth Factor 1 modulates glutamatergic and kisspeptinergic neurotransmission in ovarian steroid primed  females. Endocrinology 2014; lSS(s)1827-37:en20131682 jen2013-1682, PMID:2461752
• Bosler JS*, Davies· KP, Neal-Perry GS. Peptides in Seminal Fluid and Their  Role in Infertility: A  Potential  Role for Opiorphin Inhibition of Neutral Endopeptidase Activity as a Clinically Relevant Modulator of Sperm  Motility: A Review. Reproductive Science 2014; pii 1933719114536473, PMID:24855109
• Kudesia  R*, Neal-Perry GS. Menousal implications of polycystic ovarian syndrome. Semin  Reproductive Medicine 2014: May;32(3):222-9. Epub 2014 Apr 8. PMID: 24715517
• Harman M, Black D, Naftolin F, Brinton  E., BudoffM., Cedars M., Hopkins PN, Lobo R., Manson  J, Merriam  G, Miller V, Neal-Perry G, Santoro  N, Taylor H, Yan M, Hodis H., Arterial Imaging Outcomes  and Cardiovascular Risk Factors in Recently Menopausal Women in The Kronos Early Estrogen  Prevention Study (KEEPS): A Randomized Controlled Trial. Ann Intern Med. 2014 Jul29. doi: 10.7326/M14-0353· [Epub  ahead  of print]
• Neal-Perry G and Santoro N. Aging in Hypothalamic-Pituitary-Ovarian Axis (Chaper 51). Knobil and Neill's Physiology of Reproduction, Third Edition, ed. Jimmy Neill, Elsevier. (2006) Volume 2; 2729-2755.
• Neal-Perry G and Pal LAdnexal Masses (Chapter 4) Non-Invasive Management of Gynecological Disorders, First Edition,ed. Arici A, Seli E and Lockwood C, Informa Healthcare (2008), pages 55-62
• Neal-Perry G and Santoro NF Normal Aging and the Menopausal Transition:  What to Expect. (Chapter 1) Menopausal Transition:  The Interface Between Psychiatry and Gynecology, ed. Soares C and Warren M, Karger (2008). Vol175; 1-17
• Dickens C*; Menke M*, and Neal-Perry GS Amenorrhea: The Hypothalamic-Pituitary­ Ovarian Axis (Chapter 1pages 1-19). Diagnosis, Evaluation, and Treatment, First Edition ed (2010).  Neal-Perry GS and Santoro NF, Singer-Humana Press, NY
• Iacobas S, Neal-Perry G, Iacobas DA, Analyzing the Cytoskeletal Transcriptome: Sex Differences in Rat Hypothalamus  (Chapter 6) In: RolfDermietzel (ed.) The Cytoskeleton: Imaging, Isolation, and Interaction, Neuromethods  (2013). 79:118:133, Springer New York Heidelberg Dordrecht London

Appointments & Practice Locations

University Reproductive Care (URC)
at Women's Health Care Center, Roosevelt (WHCC)
4245 Roosevelt Way NE, 4th Floor
Seattle, WA 98105-6920

Appointments:  206.598.4225