Steiner Robert Dept web

Robert A Steiner, PhD



• BA, Biology
   (University of the Pacific, 1969)
• PhD, Physiology
   (Oregon Health Sciences University, 1975)

Research Interests:

• Reproductive neuroendocrinology
• Hormonal regulation of neuropeptide genes
• Hypothalamic neural circuitry;
   neurobiology of menopausal hot flashes
• Gene targeting; in situ hybridization; immunocytochemistry


Department of Physiology and Biophysics

Current Research:

Kisspeptin Signaling in the Brain

Professional Organizations:

• Endocrine Society
• American Physiological Society
• Society for the Study of Reproduction
• Society for Neuroscience
• International Society of Neuroendocrinology
• American Association for the Advancement of Science
• Society for Behavioral Neuroendocrinology


• Teaching Academy of the University of Washington
• Distinguished Teaching Award of the University of Washington
• William Sadler Lectureship Award, 2005
• Sir John Eccles Distinguished Lectureship Award, 2012

Selected Publications:

Popa SM, Moriyama RM, Caligioni CS, Yang JJ, Cho CM, Concepcion TL, Oakley AE, Lee IH, Sanz E, Amieux PS, Caraty A, Palmiter RD, Navarro VM, Chan YM, Seminara SB, Clifton DK, Steiner RA. Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinol 2013;154:2784-2794. [PMCID: PMC3713212]

Gill JG, Navarro VM, Kwong C, Noel SD, Martin C, Xu S, Clifton DK, Carroll RS, Steiner RA, Kaiser UB. Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid negative feedback than Kiss1. Endocrinol 2012;153:448-4893. [PMCID: PMC3512019]

Ruiz-Pino F, Navarro VM, Bentsen SH, Garcia-Galiano D, Manchez-Garrido MA, Ciofi P, Steiner RA, Mikkelsen JD, Pinilla L, Tena-Sempere M. Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids. Endocrinol 2012;153:4818-4829. [PMCID: PMC3512006]

Navarro VM, Ruiz-Pino F, Sanchez-Garrido, Garcia-Galiano D, Hobbs SJ, Manfredi-Lozano M, Leon S, Sangiano-Alvarellos S, Castellano JM, Clifton DK, Pinilla L, Steiner RA, Tena-Sempere M. Role of neurokinin B in the control of female puberty and its modulation by metabolic status. Jour of Neurosci 2012;32:2388-2397. [PMCID: PMC3567461]

Gottsch ML, Popa SM, Lawhorn JK, Qiu J, Tonsfeldt KJ, Bosch MA, Kelly MJ, Rønnekleiv OK, Sanz E, McKnight GS, Clifton DK, Palmiter RD, Steiner RA. Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinol 2011;152:4298-4309. [PMCID: PMC3199004]

Navarro VM, Gottsch ML, Wu M, Garcia-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Rønnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA. Regulation of NKB pathways and roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinol 2011;152:4265-4275 [PMCID: PMC3198996]

Kim J, Semaan SJ, Clifton DK, Steiner RA, Dhamija S, and Kauffman AS. Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinol 2011;152:2020-2030. [PMCID: PMC3075940]

Navarro VM, Castellano JM, McConkey SM, Pineda R, Ruíz-Pino F, Pinilla L, Clifton DK, Tena-Sempere M, Steiner RA. Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am Jour Physiol: Endocrinol & Metab 2011;300:E202-210.

Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K-I, Steiner RA, Okamura H. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillations of neural activity during pulsatile GnRH secretion in the goat. Jour of Neurosci 2010;30:3124-3132.

Dungan Lemko HM, Naderi R, Adjan V, Jennes LH, Navarro VM, Clifton DK, Steiner RA. Interactions between neurotensin and GnRH neurons in the positive feedback control of GnRH/LH secretion in the mouse. Am Jour of Physiol: Endocrinol & Metab 2010;298:80-88. [PMCID: PMC2806107]

Kauffman AS, Navarro VM, Kim J, Clifton DK, Steiner RA. Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am Jour of Physiol: Endocrinol & Metab 2009;297: E1212-1221.

Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA. Regulation of GnRH secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. Jour of Neurosci 2009;29:11859-11866.

Gottsch ML, Zhao Z, Glidewell-Kenney C, Weiss J, Jameson JL, Clifton DK, Levine JE, Steiner RA. Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and non-classical estrogen receptor (ER) pathways. Jour of Neurosci 2009;29:9390-9395.

Fraley GS, Steiner RA, Lent KL, Brenowitz EA. Seasonal changes in androgen receptor mRNA in the brain of the white-crowned sparrow. Gen'l and Comparative Endocrinol 2010;166:66-71.

Robertson JL, Clifton DK, Iglesia HO, Steiner RA, Kauffman AS. Circadian regulation of Kiss1 neurons: implications for the timing of the preovulatory GnRH/LH surge. Endocrinol 2009;150:3664-3671.

Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda K-I, Okamura H. Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. Jour Neuroendocrinol 2009;21:1-9.

Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan M, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Teresawa E, Clarke IJ, Steiner RA, Millar RP. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. Jour of Neurosci 2009;29:3920-3929.

Dungan Lemko HM, Clifton DK, Steiner RA, and Fraley GS. Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide GALP). Am Jour Physiol: Endocrinol and Metab 2008;295: E605-E612.

Popa SM, Clifton DK, Steiner RA. The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. Annual Review of Physiol 2008;70:213-328.