Orthopaedic Science Lab

Introduction to the OSL

The Orthopaedic Science Laboratories (OSL) broadly examines how bone responds to physical stimuli, both small and large.  We use multi-disciplinary approaches to examine basic cellular signaling pathways at levels ranging from expression of specific transcription factors in response to mechanical loading (or lack thereof) to use of complex adaptive systems biology to study the integrated behaviors of osteocyte/osteoblast networks.

Recent or Upcoming OSL Presentations

2014 35th American Society of Bone and Mineral Research Annual Meeting

Ausk, B.J., Huber, P., Gross, T.S., Srinivasan, S. (2014).  Non-invasive quantification of focal osteogenesis induced by mechanical loading.  35th ASBMR

Bain, S.D., Huber, P., Kwon, R.Y., Stoll, L., Gross, T.S. (2014).  Muscle, bone, and nerve differentially interact to achieve trabecular and cortical bone homeostasis.  35th ASBMR

Kwon, R.Y., Recidoro, A.M., Kaminsky, W. (2014).  Rotopol and microCT imaging in the regenerating zebrafish fin for BMD therapeutic discovery.  35th ASBMR

Kwon, R.Y., Virdi, A., Sumner, D.R. (2014).  Cross-species transcriptomic analysis reveals conserved osteogenic signatures during zebrafish and rat bone regeneration.  35th ASBMR

Thompson, M., Huber, P., Smith, G., Holley, A., Bain, S.D., Gardiner, E.M., Lugo, J., Kwon, R.Y. (2014).  Brain-specific PTEN deletion induces abnormal skeletal activity in mice.  35th ASBMR

Worton, L.E., Park, B., Recidoro, A.M., Gardiner, E.M., Kwon, R.Y. (2014).  Sensory neuron differentiation enhances osteoblast differentiation through soluble factors.  35th ASBMR


2014 Orthopaedic Research Society 

Ausk, B.J., Worton, L.E., Threet, D., Kwon, R.Y., Bain, S.D., Gardiner, E.M., Gross, T.S. (2014). Transient muscle paralysis predisposes bone marrow to formation of giant osteoclasts. 2014 Orthopaedic Research Society.
Roof, A.C., Recidoro, A.M., Ausk, B.J., Srinivasan, S., Gross, T.S., Gardiner, E.M., Bain, S.D., Allan, C.H., Kwon, R.Y. (2014). Chemical and mechanical nerve impairment inhibit join specification and bone formation in the regenerating zebrafish fin. 2014 Orthopaedic Research Society.
Stoll, L., Huber, P., Kwon, R.Y., Threet, D. Gross, T.S., Bain, S.D. (2014). Contralateral bone loss following ipsilateral nerve injury: Evidence for a neuronal skeletome. 2014 Orthopaedic Research Society.

2013 34th American Society of Bone and Mineral Research Annual Meeting
Recidoro, A.M., Roof, A.C., Ausk, B.J., Srinivasan, S., Gardiner, E.M., Gross, T.S., Bain, S.D., Allan, C.H., Kwon, R.Y. (2013), Neuoskeletal signaling in the regenerating zebrafish fin: remote inhibition of osteoblast function via disruption of cholinergic signaling. 34th ASBMR.

2013 Biomedical Engineering Society
Huber, P., Ausk, B.J., Gardiner, E.M., Worton, L.E., Bain, S.D., Srinivasan, S., Gross, T.S., Kwon, R.Y. (2013).  The skeleton as a complex system: emergent bone loss signatures following neuromuscular injury in zebrafish.  Biomedical Engineering Society.
Kwon, R.Y., Threet, D., Gardiner, E.M., Worton, L.E., Gross, T.S., Srinivasan, S (2013).  Timed administration of cyclosporin A supplements reveals multiple routes to rescuing loading induced bone formation at senescence.  Biomedical Engineering Society.

Rementer, C.W., Wu, M., Ausk, B.J., Gross, T.S., Giachelli, C.M. (2013).  Developing models of ectopic calcification for testing an osteoclast cell therapy.  Biomedical Engineering Society.

2013 ASME Summer Bioengineering Conference

Worton, L.E., Srinivasan, S., Kwon, R.Y. (2013) Fluid dynamic gauging-based assays for high-throughput investigation of cellular mechanotransduction. ASME 2013 Summer Bioengineering Conference.

2013 8th European Zebrafish Meeting

Huber, P., Ausk, B.J., Gardiner, E.M., Bain, S.D., Srinivasan, S., Gross, T.S., Kwon, R.Y. (2013).  Systems-based discovery in the zebrafish skeleton using micro-computed tomography.  8th European Zebrafish Meeting.

2012 ASB Annual Meeting

Ausk, B.J., Gross, T.S. (2012). Metaphyseal and Diaphyseal Bone Loss Following Transient Muscle Paralysis Are Distinct Osteoclastogenic Events  American Society of Biomechanics.  Podium

2012 ORS Annual Meeting

Gross, T.S., Gardiner, E.M., Worton, L., Bain, S.D. (2012).  Transient muscle paralysis stimulates an enhanced anabolic response to mechanical loading, Trans 57th Orthopaedic Res Soc, 175.

Worton, L., Kwon, R.Y., Gardiner, E.M., Gross, T.S., Srinivasan, S. (2012).  Cyclosporin A synergistically enhances acute gene expression and differentiation in MC3T3 cells subjected to dynamic fluid flow, Trans 57th Orthopaedic Res Soc, 1381.

Kwon, R.Y., Worton, L.E., Srinivasan, S., Gross, T.S. (2012).  Differential expression of transcriptional clusters and recurring ER1/2 activation in bone cells subjected to rest-inserted dynamic fluid flow, Trans 57th Orthopaedic Res Soc, 44.