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Tag: pregnancy
October 22, 2020
Pasteurization Inactivates SARS-CoV-2 Spiked Breast Milk
Pasteurization was shown to successfully inactivate SARS-CoV-2 in human breast milk. Conzelmann et al. spiked five different virus isolates from Germany, France, and the Netherlands into five individual milk samples. Incubating the milk samples at room temperature for 30 minutes resulted in a 40.9-92.8% drop in viral titers, and after pasteurization no further residual infectivity…
October 15, 2020
Clinical Characteristics Symptoms Management and Health Outcomes in 8598 Pregnant Women Diagnosed with COVID-19 Compared to 27510 with Seasonal Influenza in France Spain and the US
[Pre-print, not peer reviewed] A network cohort analysis of 8,598 pregnant women from France, Spain, and the US with COVID-19 found that women who were eventually hospitalized were more likely to have kidney impairment and anemia. Compared to a cohort of 27,510 pregnant women diagnosed with influenza during the 2017-2018 flu season, pregnant women with…
October 14, 2020
Impact of COVID-19 Mitigation Measures on the Incidence of Preterm Birth: A National Quasi-Experimental Study
Nationwide implementation of COVID-19 mitigation measures in the Netherlands on March 9, 2020 was associated with significant reductions in the incidence of preterm births in the following months compared to the corresponding time window immediately prior to mitigation measures (RR=0.77 to 0.85, depending on the length of the time window on either side of March…
October 13, 2020
Analysis of SARS-CoV-2 Vertical Transmission during Pregnancy. Nature Communications
Fenizia et al. report 3 cases of vertical transmission in a cohort of 31 mothers with SARS-CoV-2 infection. They also found SARS-CoV-2 RNA in umbilical cord blood from one participant, two at-term placentas, one sample from vaginal mucosa, and one milk specimen. IgM and IgG SARS-CoV-2-specific antibodies were also found in one umbilical cord blood…
Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City
Among 101 neonates born to 100 mothers with SARS-CoV-2 infection in New York City, only two newborns had positive test results for SARS-CoV-2, and none had clinical evidence of COVID-19. Seventy-six newborns shared hospital rooms with their mothers. Reasons for not sharing rooms included maternal or newborn need for ICU-level care. Ninety-one mothers breastfed. Newborns…
October 8, 2020
Women’s Perceptions of COVID-19 and Their Healthcare Experiences: A Qualitative Thematic Analysis of a National Survey of Pregnant Women in the United Kingdom
In an online survey of 1451 women who were pregnant or delivered during the pandemic in the UK, perceived barriers to seeking healthcare included “not wanting to bother anyone”, “lack of wider support from allied healthcare workers” and the influence of the media. Other concerns that arose from thematic analysis of open-ended responses included acceptability…
September 28, 2020
Risk Factors Associated with Adverse Fetal Outcomes in Pregnancies Affected by Coronavirus Disease 2019 (COVID-19): A Secondary Analysis of the WAPM Study on COVID-19
The risk of vertical transmission of SARS-CoV-2 was very low in a multinational cohort of 250 neonates born to pregnant women with COVID-19, with only 1 infant (0.4%) testing positive by RT-PCR of pharyngeal swabs performed after delivery. The infant who tested positive was asymptomatic and had a negative RT-PCR test after 14 days of…
September 24, 2020
Association of SARS-CoV-2 Test Status and Pregnancy Outcomes. JAMA. https://doi.org/10.1001/jama.2020.19124
In a Swedish study conducted among pregnant women in labor, 5.8% of 2,682 women tested positive for SARS-CoV-2 via RT-PCR. Positive patients were more likely to have preeclampsia (7.7% vs 4.3%; PR: 1.8; 95% CI: 1.0-3.4) and less likely to undergo induction of labor (18.7% vs 29.6%; PR: 0.6; 95% CI: 0.45-0.9). Other maternal and…
September 17, 2020
SARS-CoV-2 Infection Among Hospitalized Pregnant Women: Reasons for Admission and Pregnancy Characteristics — Eight U.S. Health Care Centers, March 1–May 30, 2020
Prevalence of pre-pregnancy obesity and gestational diabetes were higher among pregnant women hospitalized for COVID-19–related illness than among women admitted for obstetric reasons and later found to have COVID-19 (44% vs. 31%, and 26% vs. 8%, respectively). These findings were among 105 pregnant women hospitalized with SARS-CoV-2 in the US from March 1–May 30, 2020….
Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 — COVID-NET, 13 States, March 1–August 22, 2020
Among 598 pregnant women hospitalized with COVID-19 during March 1–August 22, 2020 in the US, 272 (45%) were symptomatic at admission, among whom 69 (25%) had severe illness during COVID-19-related hospitalizations, including ICU admissions (n=44), mechanical ventilation (n=23), and death (n=2). Ten women (7 symptomatic and 3 asymptomatic) experienced pregnancy losses. Delahoy et al. (Sept…
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