{"id":10000,"date":"2021-05-25T14:49:10","date_gmt":"2021-05-25T21:49:10","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10000"},"modified":"2021-05-27T14:49:48","modified_gmt":"2021-05-27T21:49:48","slug":"effectiveness-of-tocilizumab-in-patients-hospitalized-with-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/25\/effectiveness-of-tocilizumab-in-patients-hospitalized-with-covid-19\/","title":{"rendered":"Effectiveness of Tocilizumab in Patients Hospitalized With COVID-19"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The IL-6 inhibitor tocilizumab was not associated with a reduction in 90-day mortality (HR=0.64, 95%CI 0.25-1.65) in a follow-up of a randomized, placebo-controlled trial of patients hospitalized with COVID-19 who were receiving oxygen but did not require high-flow or mechanical ventilation (n=130). However, in a subgroup analysis including participants with baseline C-reactive protein levels greater than 15 mg\/dL, 90-day mortality was 9% in the tocilizumab group and 35% the usual care group (HR, 0.18; 95%CI 0.04-0.89). The authors caution interpretation of the findings given the small sample size and narrow study criteria (patients with a WHO Cognitive Performance Scale score of 5 exactly and requiring at least 3 L\/min of oxygen).<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Mariette et al.\u00a0(May 24, 2021). Effectiveness of Tocilizumab in Patients Hospitalized With COVID-19. JAMA Internal Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jamainternmed.2021.2209\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1001\/jamainternmed.2021.2209<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The IL-6 inhibitor tocilizumab was not associated with a reduction in 90-day mortality (HR=0.64, 95%CI 0.25-1.65) in a follow-up of a randomized, placebo-controlled trial of patients hospitalized with COVID-19 who were receiving oxygen but did not require high-flow or mechanical ventilation (n=130). However, in a subgroup analysis including participants with baseline C-reactive protein levels greater&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/25\/effectiveness-of-tocilizumab-in-patients-hospitalized-with-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-10000","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10000"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10000\/revisions"}],"predecessor-version":[{"id":10001,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10000\/revisions\/10001"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10000"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}