{"id":10012,"date":"2021-05-25T14:54:33","date_gmt":"2021-05-25T21:54:33","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10012"},"modified":"2021-05-27T14:55:14","modified_gmt":"2021-05-27T21:55:14","slug":"sars-cov-2-infection-induces-long-lived-bone-marrow-plasma-cells-in-humans","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/25\/sars-cov-2-infection-induces-long-lived-bone-marrow-plasma-cells-in-humans\/","title":{"rendered":"SARS-CoV-2 Infection Induces Long-Lived Bone Marrow Plasma Cells in Humans"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Mean anti-SARS-CoV-2 spike IgG antibody titers exhibited a biphasic decay with a rapid decay during the first 4 months followed by a more gradual decline up to 11 months in an analysis of sera from 77 convalescent individuals, most of whom had recovered from mild COVID-19. Analysis of bone marrow aspirates collected at 7-8 months and at 11 months in a subset of participants showed that frequency of spike-specific bone marrow plasma cells (BMPCs) correlated with spike-specific antibody titers, compared to aspirates from healthy controls in which BMPCs were not detected.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Turner et al.\u00a0(May 24, 2021). SARS-CoV-2 Infection Induces Long-Lived Bone Marrow Plasma Cells in Humans. Nature. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03647-4\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41586-021-03647-4<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mean anti-SARS-CoV-2 spike IgG antibody titers exhibited a biphasic decay with a rapid decay during the first 4 months followed by a more gradual decline up to 11 months in an analysis of sera from 77 convalescent individuals, most of whom had recovered from mild COVID-19. Analysis of bone marrow aspirates collected at 7-8 months&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/25\/sars-cov-2-infection-induces-long-lived-bone-marrow-plasma-cells-in-humans\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-10012","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10012"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10012\/revisions"}],"predecessor-version":[{"id":10013,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10012\/revisions\/10013"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10012"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}