{"id":10027,"date":"2021-05-26T15:04:15","date_gmt":"2021-05-26T22:04:15","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10027"},"modified":"2021-05-27T15:04:51","modified_gmt":"2021-05-27T22:04:51","slug":"sars-cov-2-antibody-testing-in-healthcare-workers-a-comparison-of-the-clinical-performance-of-three-commercially-available-antibody-assays","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/26\/sars-cov-2-antibody-testing-in-healthcare-workers-a-comparison-of-the-clinical-performance-of-three-commercially-available-antibody-assays\/","title":{"rendered":"SARS-CoV-2 Antibody Testing in Healthcare Workers a Comparison of the Clinical Performance of Three Commercially Available Antibody Assays"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A comparison of commercially available SARS-CoV-2 antibody assays found that the Roche Anti-SARS-CoV-2 anti-nucleocapsid Total Antibody test (Roche) detected antibodies for at least seven months after confirmed natural infection with while sensitivity of the Abbott Anti-SARS-CoV-2 anti-nucleocapsid IgG (Abbott) declined over time. Among serum samples from healthcare workers (N=5,788) with previously confirmed SARS-CoV-2 infection, 41% tested positive on Abbott and 95% tested positive on Roche. Sensitivity of the Abbott test started to decline at 150 days following natural infection, while Roche positivity was retained for the entire 210-day study period. These results may indicate that the Roche antibody test is better suited than Abbott to population-based studies of SARS-CoV-2 serology, though the authors note that the relationship between serologic response and functional immunity needs to be more clearly defined.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Allen et al. (May 26, 2021). SARS-CoV-2 Antibody Testing in Healthcare Workers a Comparison of the Clinical Performance of Three Commercially Available Antibody Assays. Pre-print downloaded May 26 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.25.21257772\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.25.21257772<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A comparison of commercially available SARS-CoV-2 antibody assays found that the Roche Anti-SARS-CoV-2 anti-nucleocapsid Total Antibody test (Roche) detected antibodies for at least seven months after confirmed natural infection with while sensitivity of the Abbott Anti-SARS-CoV-2 anti-nucleocapsid IgG (Abbott) declined over time. Among serum samples from healthcare workers (N=5,788) with previously confirmed&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/26\/sars-cov-2-antibody-testing-in-healthcare-workers-a-comparison-of-the-clinical-performance-of-three-commercially-available-antibody-assays\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,27],"topic":[19],"class_list":["post-10027","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-testing","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10027"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10027\/revisions"}],"predecessor-version":[{"id":10028,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10027\/revisions\/10028"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10027"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}