{"id":10037,"date":"2021-05-26T15:08:26","date_gmt":"2021-05-26T22:08:26","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10037"},"modified":"2021-05-27T15:09:14","modified_gmt":"2021-05-27T22:09:14","slug":"influence-of-past-infection-with-sars-cov-2-on-the-response-to-the-biotech-pfizer-bnt162b2-mrna-vaccine-in-health-care-workers-kinetics-and-durability-of-the-humoral-response","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/26\/influence-of-past-infection-with-sars-cov-2-on-the-response-to-the-biotech-pfizer-bnt162b2-mrna-vaccine-in-health-care-workers-kinetics-and-durability-of-the-humoral-response\/","title":{"rendered":"Influence of Past Infection with SARS-CoV-2 on the Response to the BioTech Pfizer BNT162b2 MRNA Vaccine in Health Care Workers Kinetics and Durability of the Humoral Response"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A cohort study of 63 hospital healthcare workers in Spain who received 2 doses of the Pfizer-BioNTech vaccine found that those with a previous SARS-CoV-2 infection developed a 126-fold increase in antibody levels after 1 dose and maintained higher antibody levels than SARS-CoV-2 na\u00efve workers after the 2<\/span><span style=\"font-weight: 400\">nd<\/span><span style=\"font-weight: 400\"> dose. Healthcare workers with history of SARS-CoV-2 infection did not experience an increase in antibodies after the second dose, while SARS-CoV-2 na\u00efve workers had a significant increase in antibody levels. The authors suggest these results may indicate the persistence of strong immunologic memory in persons with past SARS-CoV-2 infection and that vaccination of these persons could potentially be postponed as a strategy to optimize vaccine allocation.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Ontanon et al. (May 26, 2021). Influence of Past Infection with SARS-CoV-2 on the Response to the BioTech Pfizer BNT162b2 MRNA Vaccine in Health Care Workers Kinetics and Durability of the Humoral Response. Pre-print downloaded May 26 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.25.21257788\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.25.21257788<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A cohort study of 63 hospital healthcare workers in Spain who received 2 doses of the Pfizer-BioNTech vaccine found that those with a previous SARS-CoV-2 infection developed a 126-fold increase in antibody levels after 1 dose and maintained higher antibody levels than SARS-CoV-2 na\u00efve workers after the 2nd dose. Healthcare workers with&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/26\/influence-of-past-infection-with-sars-cov-2-on-the-response-to-the-biotech-pfizer-bnt162b2-mrna-vaccine-in-health-care-workers-kinetics-and-durability-of-the-humoral-response\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,32,142],"topic":[31],"class_list":["post-10037","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-immunity","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10037"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10037\/revisions"}],"predecessor-version":[{"id":10038,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10037\/revisions\/10038"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10037"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}