{"id":10039,"date":"2021-05-26T15:09:22","date_gmt":"2021-05-26T22:09:22","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10039"},"modified":"2021-05-27T15:10:12","modified_gmt":"2021-05-27T22:10:12","slug":"single-dose-sars-cov-2-vaccine-in-a-prospective-cohort-of-covid-19-patients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/26\/single-dose-sars-cov-2-vaccine-in-a-prospective-cohort-of-covid-19-patients\/","title":{"rendered":"Single-Dose SARS-CoV-2 Vaccine in a Prospective Cohort of COVID-19 Patients"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A study comparing antibody responses in 155 previously SARS-CoV-2 infected individuals found a single dose of the Pfizer-BioNTech vaccine provided neutralizing antibody titers exceeding those produced following two vaccine doses in 49 previously uninfected healthcare workers. Additionally, pre-vaccination neutralization titers in persons with previous infection were associated with higher neutralization titers after vaccination, independent of disease severity or time since infection up to 15 months after SARS-CoV-2 infection. Serum samples from a random selection of 20 participants with previous infection and one dose also demonstrated cross-neutralization of variants B.1.351, P.1, and B.1.1.7.\u00a0 The authors suggest these findings support implementation of a single-dose mRNA vaccine strategy in persons with prior SARS-CoV-2 infection.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Gils et al. (May 25, 2021). Single-Dose SARS-CoV-2 Vaccine in a Prospective Cohort of COVID-19 Patients. Pre-print downloaded May 26 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.25.21257797\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.25.21257797<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A study comparing antibody responses in 155 previously SARS-CoV-2 infected individuals found a single dose of the Pfizer-BioNTech vaccine provided neutralizing antibody titers exceeding those produced following two vaccine doses in 49 previously uninfected healthcare workers. Additionally, pre-vaccination neutralization titers in persons with previous infection were associated with higher neutralization titers after&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/26\/single-dose-sars-cov-2-vaccine-in-a-prospective-cohort-of-covid-19-patients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,32,142,141],"topic":[31],"class_list":["post-10039","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-immunity","tag-vaccine","tag-variant","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10039"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10039\/revisions"}],"predecessor-version":[{"id":10040,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10039\/revisions\/10040"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10039"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}