{"id":10066,"date":"2021-05-27T15:29:39","date_gmt":"2021-05-27T22:29:39","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10066"},"modified":"2021-05-28T15:30:21","modified_gmt":"2021-05-28T22:30:21","slug":"cellular-and-humoral-response-after-mrna-1273-sars-cov-2-vaccine-in-kidney-transplant-recipients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/27\/cellular-and-humoral-response-after-mrna-1273-sars-cov-2-vaccine-in-kidney-transplant-recipients\/","title":{"rendered":"Cellular and Humoral Response after MRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Only 35 of 117 (30%) kidney transplant recipients without known prior SARS-CoV-2 infection had a detectable humoral immune response (anti-spike IgG and\/or IgM antibodies) to the Moderna vaccine two weeks after the second dose, while 55% had a detectable cellular immune response. Development of both humoral and cellular immune responses was observed in 20% of patients. In total, only 65% presented with any immune response to vaccination. Baseline immunosuppression was associated with a lack of humoral response.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Cucchiari et al.\u00a0(May 26, 2021). Cellular and Humoral Response after MRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients. American Journal of Transplantation. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/ajt.16701\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1111\/ajt.16701<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Only 35 of 117 (30%) kidney transplant recipients without known prior SARS-CoV-2 infection had a detectable humoral immune response (anti-spike IgG and\/or IgM antibodies) to the Moderna vaccine two weeks after the second dose, while 55% had a detectable cellular immune response. Development of both humoral and cellular immune responses was observed in 20% of&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/27\/cellular-and-humoral-response-after-mrna-1273-sars-cov-2-vaccine-in-kidney-transplant-recipients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[201,32],"topic":[31],"class_list":["post-10066","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immune-response","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10066"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10066\/revisions"}],"predecessor-version":[{"id":10067,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10066\/revisions\/10067"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10066"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10066"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10066"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}