{"id":10072,"date":"2021-05-27T15:32:19","date_gmt":"2021-05-27T22:32:19","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10072"},"modified":"2021-05-28T15:33:11","modified_gmt":"2021-05-28T22:33:11","slug":"distinct-cytokine-and-chemokine-dysregulation-in-hospitalized-children-with-acute-covid-19-and-multisystem-inflammatory-syndrome-with-similar-levels-of-nasopharyngeal-sars-cov-2-shedding","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/27\/distinct-cytokine-and-chemokine-dysregulation-in-hospitalized-children-with-acute-covid-19-and-multisystem-inflammatory-syndrome-with-similar-levels-of-nasopharyngeal-sars-cov-2-shedding\/","title":{"rendered":"Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children with Acute COVID-19 and Multisystem Inflammatory Syndrome with Similar Levels of Nasopharyngeal SARS-CoV-2 Shedding"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In a cohort study of individuals aged &lt;18 years who were hospitalized with COVID-19 (n=32), those diagnosed with multisystem inflammatory syndrome in children (MIS-C) (n=16) had significantly higher levels of cytokine and chemokines, such as IL-6 and IL-8, and were more likely to have anti-SARS-CoV-2 antibody positivity (75% vs 44%) compared to those without MIS-C. MIS-C patients tended to be younger (median age 2.2 years vs 8.7 years), but nasopharyngeal viral load did not differ significantly between the two groups.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Akindele et al.\u00a0(May 24, 2021). Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children with Acute COVID-19 and Multisystem Inflammatory Syndrome with Similar Levels of Nasopharyngeal SARS-CoV-2 Shedding. The Journal of Infectious Diseases. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/infdis\/jiab285\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1093\/infdis\/jiab285<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a cohort study of individuals aged &lt;18 years who were hospitalized with COVID-19 (n=32), those diagnosed with multisystem inflammatory syndrome in children (MIS-C) (n=16) had significantly higher levels of cytokine and chemokines, such as IL-6 and IL-8, and were more likely to have anti-SARS-CoV-2 antibody positivity (75% vs 44%) compared to those without MIS-C&#8230;.<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/27\/distinct-cytokine-and-chemokine-dysregulation-in-hospitalized-children-with-acute-covid-19-and-multisystem-inflammatory-syndrome-with-similar-levels-of-nasopharyngeal-sars-cov-2-shedding\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[41,34],"topic":[20],"class_list":["post-10072","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-children","tag-clinical-characteristics","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10072"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10072\/revisions"}],"predecessor-version":[{"id":10073,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10072\/revisions\/10073"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10072"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}