{"id":10074,"date":"2021-05-27T15:33:17","date_gmt":"2021-05-27T22:33:17","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10074"},"modified":"2021-05-28T15:34:05","modified_gmt":"2021-05-28T22:34:05","slug":"type-i-ii-and-iii-interferon-signatures-correspond-to-covid-19-disease-severity","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/27\/type-i-ii-and-iii-interferon-signatures-correspond-to-covid-19-disease-severity\/","title":{"rendered":"Type I, II, and III Interferon Signatures Correspond to COVID-19 Disease Severity"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In an analysis of plasma levels of interferons (IFNs) and cytokines among patients with SARS-CoV-2 infection and varying disease severity (n=67), type I IFN responses appeared to be transient among those with mild disease but prolonged among those admitted to the ICU. Plasma levels of type II IFNs were comparable among patients overall and induced early in disease course. Like type I IFNs, cytokine and chemokine levels correlated with disease severity and were highest in ICU patients.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Kim et al.\u00a0(May 24, 2021). Type I, II, and III Interferon Signatures Correspond to COVID-19 Disease Severity. The Journal of Infectious Diseases. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/infdis\/jiab288\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1093\/infdis\/jiab288<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In an analysis of plasma levels of interferons (IFNs) and cytokines among patients with SARS-CoV-2 infection and varying disease severity (n=67), type I IFN responses appeared to be transient among those with mild disease but prolonged among those admitted to the ICU. Plasma levels of type II IFNs were comparable among patients overall and induced&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/27\/type-i-ii-and-iii-interferon-signatures-correspond-to-covid-19-disease-severity\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34,201,153],"topic":[20],"class_list":["post-10074","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","tag-immune-response","tag-other-resources","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10074"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10074\/revisions"}],"predecessor-version":[{"id":10075,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10074\/revisions\/10075"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10074"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}