{"id":10089,"date":"2021-05-28T10:23:09","date_gmt":"2021-05-28T17:23:09","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10089"},"modified":"2021-06-01T10:23:58","modified_gmt":"2021-06-01T17:23:58","slug":"e484k-as-an-innovative-phylogenetic-event-for-viral-evolution-genomic-analysis-of-the-e484k-spike-mutation-in-sars-cov-2-lineages-from-brazil","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/28\/e484k-as-an-innovative-phylogenetic-event-for-viral-evolution-genomic-analysis-of-the-e484k-spike-mutation-in-sars-cov-2-lineages-from-brazil\/","title":{"rendered":"E484K as an Innovative Phylogenetic Event for Viral Evolution: Genomic Analysis of the E484K Spike Mutation in SARS-CoV-2 Lineages from Brazil"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Genomic and phylogenetic analyses of SARS-CoV-2 genomes with the E484K mutation sequenced from samples in Brazil in 2020 showed that over 40% of sequenced genomes had this mutation by October 2020 across three distinct lineages (P.1, P.2, and N.9) in four different regions. Modeling of a random set of sequenced genomes suggests that the mutation is under positive selection in lineages in Brazil.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Ferrareze et al.\u00a0(May 25, 2021). E484K as an Innovative Phylogenetic Event for Viral Evolution: Genomic Analysis of the E484K Spike Mutation in SARS-CoV-2 Lineages from Brazil. Infection, Genetics and Evolution. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.meegid.2021.104941\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.meegid.2021.104941<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genomic and phylogenetic analyses of SARS-CoV-2 genomes with the E484K mutation sequenced from samples in Brazil in 2020 showed that over 40% of sequenced genomes had this mutation by October 2020 across three distinct lineages (P.1, P.2, and N.9) in four different regions. Modeling of a random set of sequenced genomes suggests that the mutation&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/28\/e484k-as-an-innovative-phylogenetic-event-for-viral-evolution-genomic-analysis-of-the-e484k-spike-mutation-in-sars-cov-2-lineages-from-brazil\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,159],"topic":[31],"class_list":["post-10089","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10089"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10089\/revisions"}],"predecessor-version":[{"id":10090,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10089\/revisions\/10090"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10089"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}