{"id":10129,"date":"2021-06-01T11:26:48","date_gmt":"2021-06-01T18:26:48","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10129"},"modified":"2021-06-03T11:27:37","modified_gmt":"2021-06-03T18:27:37","slug":"cellular-and-humoral-immunogenicity-of-a-sars-cov-2-mrna-vaccine-in-patients-on-hemodialysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/01\/cellular-and-humoral-immunogenicity-of-a-sars-cov-2-mrna-vaccine-in-patients-on-hemodialysis\/","title":{"rendered":"Cellular and Humoral Immunogenicity of a SARS-CoV-2 MRNA Vaccine in Patients on Hemodialysis"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> In a cohort of patients on intermittent hemodialysis (n=81), the Pfizer-BioNTech vaccine elicited diminished anti-SARS-CoV-2 antibody responses compared to healthy controls (n=34). Plasma and saliva IgG responses and antibody binding to variants of concern were lower in dialysis patients, particularly binding against the B.1.351 variant. Consistent with humoral responses, vaccine-induced cellular immune responses assessed by T-cell mediated interferon \u03b3 release after stimulation with SARS-CoV-2 spike peptides were significantly diminished in dialysis patients.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Strengert et al.\u00a0(May 29, 2021). Cellular and Humoral Immunogenicity of a SARS-CoV-2 MRNA Vaccine in Patients on Hemodialysis. Pre-print downloaded Jun 1 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.26.21257860\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.26.21257860<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] In a cohort of patients on intermittent hemodialysis (n=81), the Pfizer-BioNTech vaccine elicited diminished anti-SARS-CoV-2 antibody responses compared to healthy controls (n=34). Plasma and saliva IgG responses and antibody binding to variants of concern were lower in dialysis patients, particularly binding against the B.1.351 variant. Consistent with humoral responses, vaccine-induced cellular immune&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/01\/cellular-and-humoral-immunogenicity-of-a-sars-cov-2-mrna-vaccine-in-patients-on-hemodialysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[230],"topic":[31],"class_list":["post-10129","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine-effectiveness","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10129"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10129\/revisions"}],"predecessor-version":[{"id":10130,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10129\/revisions\/10130"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10129"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}