{"id":10131,"date":"2021-06-01T11:27:52","date_gmt":"2021-06-01T18:27:52","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10131"},"modified":"2021-06-03T11:28:30","modified_gmt":"2021-06-03T18:28:30","slug":"sars-cov-2-antibody-kinetics-eight-months-from-covid-19-onset-persistence-of-spike-antibodies-but-loss-of-neutralizing-antibodies-in-24-of-convalescent-plasma-donors","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/01\/sars-cov-2-antibody-kinetics-eight-months-from-covid-19-onset-persistence-of-spike-antibodies-but-loss-of-neutralizing-antibodies-in-24-of-convalescent-plasma-donors\/","title":{"rendered":"SARS-CoV-2 Antibody Kinetics Eight Months from COVID-19 Onset: Persistence of Spike Antibodies but Loss of Neutralizing Antibodies in 24% of Convalescent Plasma Donors"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Following infection with SARS-CoV-2, the half-life of SARS-CoV-2 neutralizing antibodies was shorter than the half-life of antibodies directed against spike or nucleocapsid. In a cohort study of 148 individuals followed for a median of 8.3 months, antibodies followed a biphasic decay curve. Neutralizing antibody titers contracted the fastest, with an estimated half-life of 47 days in the first 0-6 months following infection and 27 days beyond 6 months post-infection. The half-life of anti-SARS-CoV-2 spike antibodies was estimated to be 97 days 0-6 months after symptom onset and 169 days 6 months or more after symptom onset. Anti-nucleocapsid antibodies declined faster than spike with half-life estimates of 47 and 168 days 0-6 months and 6 months or more after symptom onset, respectively. Older age (&gt;50 years) and hospitalization were associated with higher antibody levels.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Terpos et al.\u00a0(May 2021). SARS-CoV-2 Antibody Kinetics Eight Months from COVID-19 Onset: Persistence of Spike Antibodies but Loss of Neutralizing Antibodies in 24% of Convalescent Plasma Donors. European Journal of Internal Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.ejim.2021.05.010\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.ejim.2021.05.010<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Following infection with SARS-CoV-2, the half-life of SARS-CoV-2 neutralizing antibodies was shorter than the half-life of antibodies directed against spike or nucleocapsid. In a cohort study of 148 individuals followed for a median of 8.3 months, antibodies followed a biphasic decay curve. Neutralizing antibody titers contracted the fastest, with an estimated half-life of 47 days&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/01\/sars-cov-2-antibody-kinetics-eight-months-from-covid-19-onset-persistence-of-spike-antibodies-but-loss-of-neutralizing-antibodies-in-24-of-convalescent-plasma-donors\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-10131","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10131"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10131\/revisions"}],"predecessor-version":[{"id":10132,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10131\/revisions\/10132"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10131"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10131"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10131"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}