{"id":10145,"date":"2021-06-02T11:49:29","date_gmt":"2021-06-02T18:49:29","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10145"},"modified":"2021-06-03T11:50:15","modified_gmt":"2021-06-03T18:50:15","slug":"emerging-sars-cov-2-variants-of-concern-evade-humoral-immune-responses-from-infection-and-vaccination","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/02\/emerging-sars-cov-2-variants-of-concern-evade-humoral-immune-responses-from-infection-and-vaccination\/","title":{"rendered":"Emerging SARS-CoV-2 Variants of Concern Evade Humoral Immune Responses from Infection and Vaccination"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Anti-SARS-CoV-2 antibody binding and neutralizing activity in sera of both convalescent individuals who had recovered from infection that occurred prior to the spread of variants of concern (VOC) (n=69) and recipients of the Pfizer-BioNTech vaccine (n=50) were reduced against the B.1.1.7, B.1.351, and P.1 VOC, according to a cohort study. The largest reductions in neutralization were up to 4- to 7-fold by the B.1351 variant. While hospitalized COVID-19 patients and vaccinated individuals produced sufficient neutralizing activity against all variants, nearly 4 in 10 non-hospitalized patients did not neutralize B.1.351. Binding activity of monoclonal antibody treatments targeting the receptor binding domain were substantially reduced against B.1.351, but not against B.1.1.7.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Caniels et al.\u00a0(June 1, 2021). Emerging SARS-CoV-2 Variants of Concern Evade Humoral Immune Responses from Infection and Vaccination. Pre-print downloaded Jun 2 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.26.21257441\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.26.21257441<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Anti-SARS-CoV-2 antibody binding and neutralizing activity in sera of both convalescent individuals who had recovered from infection that occurred prior to the spread of variants of concern (VOC) (n=69) and recipients of the Pfizer-BioNTech vaccine (n=50) were reduced against the B.1.1.7, B.1.351, and P.1 VOC, according to a cohort study. The largest&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/02\/emerging-sars-cov-2-variants-of-concern-evade-humoral-immune-responses-from-infection-and-vaccination\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,159],"topic":[31],"class_list":["post-10145","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10145"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10145\/revisions"}],"predecessor-version":[{"id":10146,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10145\/revisions\/10146"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10145"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}