{"id":10180,"date":"2021-06-03T15:09:49","date_gmt":"2021-06-03T22:09:49","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10180"},"modified":"2021-06-04T15:10:43","modified_gmt":"2021-06-04T22:10:43","slug":"efficacy-and-safety-of-covid-19-vaccines-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/03\/efficacy-and-safety-of-covid-19-vaccines-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials\/","title":{"rendered":"Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In a systematic review and meta-analysis of 25 randomized trials assessing safety and efficacy of COVID-19 vaccines, mRNA-based (e.g., Pfizer-BioNTech and Moderna) and adenovirus-vectored (e.g., Oxford-AstraZeneca, Johnson &amp; Johnson, Sputnik V) vaccines had the highest efficacy in phase 2\/3 trials (94.6% and 80.2%, respectively). The mRNA-based vaccines had the highest level of side effects reported, except for diarrhea and joint pain (arthralgia). All vaccines stimulated robust immune responses. Among 58,889 participants who received a COVID-19 vaccine and 46,638 controls who received a placebo included in the analysis, few extreme adverse effects were observed.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Pormohammad et al.\u00a0(May 6, 2021). Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Vaccines. <\/span><\/i><a href=\"https:\/\/doi.org\/10.3390\/vaccines9050467\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.3390\/vaccines9050467<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a systematic review and meta-analysis of 25 randomized trials assessing safety and efficacy of COVID-19 vaccines, mRNA-based (e.g., Pfizer-BioNTech and Moderna) and adenovirus-vectored (e.g., Oxford-AstraZeneca, Johnson &amp; Johnson, Sputnik V) vaccines had the highest efficacy in phase 2\/3 trials (94.6% and 80.2%, respectively). The mRNA-based vaccines had the highest level of side effects reported,&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/03\/efficacy-and-safety-of-covid-19-vaccines-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[233,230,33],"topic":[31],"class_list":["post-10180","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-adverse-events","tag-vaccine-effectiveness","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10180"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10180\/revisions"}],"predecessor-version":[{"id":10181,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10180\/revisions\/10181"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10180"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}