{"id":10184,"date":"2021-06-03T15:11:46","date_gmt":"2021-06-03T22:11:46","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10184"},"modified":"2021-06-04T15:12:34","modified_gmt":"2021-06-04T22:12:34","slug":"sars-cov-2-infects-syncytiotrophoblast-and-activates-inflammatory-responses-in-the-placenta","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/03\/sars-cov-2-infects-syncytiotrophoblast-and-activates-inflammatory-responses-in-the-placenta\/","title":{"rendered":"SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> SARS-CoV-2 RNA was detected in 23 placentas (41%) from a cohort of 55 women who had SARS-CoV-2 infection during late pregnancy and had positive PCR results at delivery. Among infected placentas, three had high viral content and were obtained from mothers who presented with severe COVID-19 and had perinatal adverse outcomes. Examination of the placentas with high viral load showed efficient SARS-CoV-2 infection restricted to\u00a0 syncytiotrophoblast cells, which envelope the fetal chorionic villi and are in direct contact with maternal blood, and considerable infiltration of maternal immune cells.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Argueta et al.\u00a0(June 2, 2021). SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta. Pre-print downloaded Jun 3 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.06.01.446676\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.06.01.446676<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] SARS-CoV-2 RNA was detected in 23 placentas (41%) from a cohort of 55 women who had SARS-CoV-2 infection during late pregnancy and had positive PCR results at delivery. Among infected placentas, three had high viral content and were obtained from mothers who presented with severe COVID-19 and had perinatal adverse outcomes. Examination&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/03\/sars-cov-2-infects-syncytiotrophoblast-and-activates-inflammatory-responses-in-the-placenta\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34,32,50],"topic":[20],"class_list":["post-10184","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","tag-immunity","tag-pregnancy","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10184"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10184\/revisions"}],"predecessor-version":[{"id":10185,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10184\/revisions\/10185"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10184"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}