{"id":10206,"date":"2021-06-04T10:35:26","date_gmt":"2021-06-04T17:35:26","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10206"},"modified":"2021-06-08T10:36:10","modified_gmt":"2021-06-08T17:36:10","slug":"prevention-and-attenuation-of-covid-19-by-bnt162b2-and-mrna-1273-vaccines","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/04\/prevention-and-attenuation-of-covid-19-by-bnt162b2-and-mrna-1273-vaccines\/","title":{"rendered":"Prevention and Attenuation of COVID-19 by BNT162b2 and mRNA-1273 Vaccines"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A prospective cohort study (N=3,975) of healthcare personnel and other frontline workers estimated the real-world effectiveness of Pfizer-BioNTech and Moderna COVID-19 vaccines and found that the adjusted effectiveness of full vaccination was 92% (95% CI 76-97%) and effectiveness of partial vaccination was 81% (95% CI 64-90%). Additionally, among partially or fully vaccinated participants who became infected SARS-CoV-2, mean viral RNA load was 40% lower, the risk of self-reported febrile COVID-19 was 58% lower, and vaccinated individuals experienced 2.3 fewer days spent sick in bed compared to unvaccinated participants with SARS-CoV-2 infection. The authors conclude that these results indicate that mRNA vaccines are highly effective among working-age adults in preventing SARS-CoV-2 infection and decreasing viral load, symptoms, and illness duration.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Thompson et al.\u00a0(June 3, 2021). Prevention and Attenuation of COVID-19 by BNT162b2 and mRNA-1273 Vaccines. Pre-print downloaded Jun 4 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.06.01.21257987\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.06.01.21257987<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A prospective cohort study (N=3,975) of healthcare personnel and other frontline workers estimated the real-world effectiveness of Pfizer-BioNTech and Moderna COVID-19 vaccines and found that the adjusted effectiveness of full vaccination was 92% (95% CI 76-97%) and effectiveness of partial vaccination was 81% (95% CI 64-90%). Additionally, among partially or fully vaccinated&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/04\/prevention-and-attenuation-of-covid-19-by-bnt162b2-and-mrna-1273-vaccines\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,33],"topic":[31],"class_list":["post-10206","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10206"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10206\/revisions"}],"predecessor-version":[{"id":10207,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10206\/revisions\/10207"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10206"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}