{"id":10210,"date":"2021-06-04T10:37:25","date_gmt":"2021-06-04T17:37:25","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10210"},"modified":"2021-06-08T10:38:13","modified_gmt":"2021-06-08T17:38:13","slug":"immunological-dysfunction-persists-for-8-months-following-initial-mild-moderate-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/04\/immunological-dysfunction-persists-for-8-months-following-initial-mild-moderate-sars-cov-2-infection\/","title":{"rendered":"Immunological Dysfunction Persists for 8 Months Following Initial Mild-Moderate SARS-CoV-2 Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A prospective cohort study found that persons with persistent symptoms following COVID-19 infection had an elevated diffuse inflammatory cytokine profile at 8 months post SARS-CoV-2 infection, which was not observed in age\/gender matched asymptomatic COVID-19 survivors, healthy controls, or persons who survived other human coronaviruses. Additionally, persons with persisting symptoms had a lack of na\u00efve T and B cell reconstitution, suggesting immunological inflammation at a cellular level. The authors hypothesize that this prolonged inflammation and abnormal immune profile may be the underlying cause of symptomologies characterized as \u201clong COVID\u201d.\u00a0\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Phetsouphanh et al.\u00a0(June 3, 2021). Immunological Dysfunction Persists for 8 Months Following Initial Mild-Moderate SARS-CoV-2 Infection. Pre-print downloaded Jun 4 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.06.01.21257759\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.06.01.21257759<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A prospective cohort study found that persons with persistent symptoms following COVID-19 infection had an elevated diffuse inflammatory cytokine profile at 8 months post SARS-CoV-2 infection, which was not observed in age\/gender matched asymptomatic COVID-19 survivors, healthy controls, or persons who survived other human coronaviruses. Additionally, persons with persisting symptoms had a&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/04\/immunological-dysfunction-persists-for-8-months-following-initial-mild-moderate-sars-cov-2-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34,236],"topic":[20],"class_list":["post-10210","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","tag-longcovid","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10210"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10210\/revisions"}],"predecessor-version":[{"id":10211,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10210\/revisions\/10211"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10210"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}