{"id":10258,"date":"2021-06-08T13:13:58","date_gmt":"2021-06-08T20:13:58","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10258"},"modified":"2021-06-09T13:14:32","modified_gmt":"2021-06-09T20:14:32","slug":"improved-diagnosis-of-sars-cov-2-by-using-nucleoprotein-and-spike-protein-fragment-2-in-quantitative-dual-elisa-tests","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/08\/improved-diagnosis-of-sars-cov-2-by-using-nucleoprotein-and-spike-protein-fragment-2-in-quantitative-dual-elisa-tests\/","title":{"rendered":"Improved Diagnosis of SARS-CoV-2 by Using Nucleoprotein and Spike Protein Fragment 2 in Quantitative Dual ELISA Tests"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A combination of two quantitative ELISA assays using SARS-CoV-2 nucleocapsid (N) and spike subunit 2 (S2) was able to detect at least 10% more true positive COVID-19 cases compared to a commercially available antibody test (Abbott) when tested against a panel of 42 SARS-CoV-2 positive serum samples and 37 negative control samples. Analysis of assay results showed that S2-specific antibody activity specific was weaker and also declined more rapidly.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Verissimo et al.\u00a0(June 8, 2021). Improved Diagnosis of SARS-CoV-2 by Using Nucleoprotein and Spike Protein Fragment 2 in Quantitative Dual ELISA Tests. Epidemiology and Infection. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1017\/S0950268821001308\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1017\/S0950268821001308<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A combination of two quantitative ELISA assays using SARS-CoV-2 nucleocapsid (N) and spike subunit 2 (S2) was able to detect at least 10% more true positive COVID-19 cases compared to a commercially available antibody test (Abbott) when tested against a panel of 42 SARS-CoV-2 positive serum samples and 37 negative control samples. Analysis of assay&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/08\/improved-diagnosis-of-sars-cov-2-by-using-nucleoprotein-and-spike-protein-fragment-2-in-quantitative-dual-elisa-tests\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[27],"topic":[19],"class_list":["post-10258","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-testing","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10258"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10258\/revisions"}],"predecessor-version":[{"id":10259,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10258\/revisions\/10259"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10258"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}