{"id":10260,"date":"2021-06-08T13:14:40","date_gmt":"2021-06-08T20:14:40","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10260"},"modified":"2021-06-09T13:15:24","modified_gmt":"2021-06-09T20:15:24","slug":"nanobodies-from-camelid-mice-and-llamas-neutralize-sars-cov-2-variants","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/08\/nanobodies-from-camelid-mice-and-llamas-neutralize-sars-cov-2-variants\/","title":{"rendered":"Nanobodies from Camelid Mice and Llamas Neutralize SARS-CoV-2 Variants"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Two groups of single-domain antibodies, known as nanobodies, isolated from llamas and genetically engineered mice was identified to possess anti-SARS-CoV-2 receptor binding domain (RBD) neutralizing activity. The first group is able to bind to a region in the RBD largely preserved across SARS-CoV-2 mutations but rarely targeted by human antibodies, while the second group demonstrated high neutralizing activity against variants of concern when expressed as homotrimers.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Xu et al.\u00a0(June 7, 2021). Nanobodies from Camelid Mice and Llamas Neutralize SARS-CoV-2 Variants. Nature. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03676-z\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41586-021-03676-z<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two groups of single-domain antibodies, known as nanobodies, isolated from llamas and genetically engineered mice was identified to possess anti-SARS-CoV-2 receptor binding domain (RBD) neutralizing activity. The first group is able to bind to a region in the RBD largely preserved across SARS-CoV-2 mutations but rarely targeted by human antibodies, while the second group demonstrated&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/08\/nanobodies-from-camelid-mice-and-llamas-neutralize-sars-cov-2-variants\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28,159],"topic":[19],"class_list":["post-10260","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","tag-variants","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10260"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10260\/revisions"}],"predecessor-version":[{"id":10261,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10260\/revisions\/10261"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10260"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}