{"id":10270,"date":"2021-06-08T13:19:12","date_gmt":"2021-06-08T20:19:12","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10270"},"modified":"2021-06-09T13:19:55","modified_gmt":"2021-06-09T20:19:55","slug":"long-covid-following-mild-sars-cov-2-infection-characteristic-t-cell-alterations-and-response-to-antihistamines","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/08\/long-covid-following-mild-sars-cov-2-infection-characteristic-t-cell-alterations-and-response-to-antihistamines\/","title":{"rendered":"Long-COVID Following Mild SARS CoV-2 Infection Characteristic T Cell Alterations and Response to Antihistamines"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> \u201cLong COVID\u201d patients with persistent symptoms (mean symptom duration 269 days) treated with histamine receptor antagonists (HRA) (n=25) reported an average reduction in symptom burden by 60%. 20% reported complete symptom resolution, 52% experienced some improvement, and 6 reported no change with a mean time to response of 30 days. By contrast, the 67% of untreated cohort (n=24) reported no change and 8% developed new additional symptoms. Long COVID patients had distinct T-cell profiles compared with 16 controls who recovered from COVID-19 but did not have long COVID, including reduced CD4+ and CD8+ effector memory cells. However, T-cell profiles did not predict responses to HRA.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Glynne et al.\u00a0(June 7, 2021). Long-COVID Following Mild SARS CoV-2 Infection Characteristic T Cell Alterations and Response to Antihistamines. Pre-print downloaded Jun 8 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.06.06.21258272\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.06.06.21258272<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] \u201cLong COVID\u201d patients with persistent symptoms (mean symptom duration 269 days) treated with histamine receptor antagonists (HRA) (n=25) reported an average reduction in symptom burden by 60%. 20% reported complete symptom resolution, 52% experienced some improvement, and 6 reported no change with a mean time to response of 30 days. By contrast,&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/08\/long-covid-following-mild-sars-cov-2-infection-characteristic-t-cell-alterations-and-response-to-antihistamines\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34,51],"topic":[20],"class_list":["post-10270","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","tag-sequelae","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10270"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10270\/revisions"}],"predecessor-version":[{"id":10271,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10270\/revisions\/10271"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10270"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}