{"id":10297,"date":"2021-06-09T11:28:32","date_gmt":"2021-06-09T18:28:32","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10297"},"modified":"2021-06-10T11:30:16","modified_gmt":"2021-06-10T18:30:16","slug":"delayed-antibody-and-t-cell-response-to-bnt162b2-vaccination-in-the-elderly-germany","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/09\/delayed-antibody-and-t-cell-response-to-bnt162b2-vaccination-in-the-elderly-germany\/","title":{"rendered":"Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In a cohort of elderly residents of an assisted living facility in Germany (n=71, median age 81 years) vaccinated with the Pfizer-BioNTech vaccine only 46% (24 of 52) developed neutralizing antibodies 3 weeks after the first dose and 90% (63 of 70) 4 weeks after the second dose. In contrast, 91% (97 of 107) of vaccinated healthcare workers (n=123, median age 34 years) had neutralizing antibody 3 weeks after the first dose. Similarly, IgG responses against SARS-CoV-2 antigens and spike-specific T-cell responses were both delayed and reduced in the older cohort throughout the study.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Schwarz et al.\u00a0(June 8, 2021). Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany. Emerging Infectious Diseases. <\/span><\/i><a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/27\/8\/21-1145_article\"><span style=\"font-weight: 400\">https:\/\/wwwnc.cdc.gov\/eid\/article\/27\/8\/21-1145_article<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a cohort of elderly residents of an assisted living facility in Germany (n=71, median age 81 years) vaccinated with the Pfizer-BioNTech vaccine only 46% (24 of 52) developed neutralizing antibodies 3 weeks after the first dose and 90% (63 of 70) 4 weeks after the second dose. In contrast, 91% (97 of 107) of&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/09\/delayed-antibody-and-t-cell-response-to-bnt162b2-vaccination-in-the-elderly-germany\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,239,33],"topic":[31],"class_list":["post-10297","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-breakthrough-infection","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10297"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10297\/revisions"}],"predecessor-version":[{"id":10298,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10297\/revisions\/10298"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10297"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}