{"id":10313,"date":"2021-06-10T10:29:32","date_gmt":"2021-06-10T17:29:32","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10313"},"modified":"2021-06-11T10:30:15","modified_gmt":"2021-06-11T17:30:15","slug":"immunogenicity-of-ad26-cov2-s-vaccine-against-sars-cov-2-variants-in-humans","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/10\/immunogenicity-of-ad26-cov2-s-vaccine-against-sars-cov-2-variants-in-humans\/","title":{"rendered":"Immunogenicity of Ad26.COV2.S Vaccine against SARS-CoV-2 Variants in Humans"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Median anti-SARS-CoV-2 neutralizing antibody titers of sera from individuals vaccinated with the Johnson &amp; Johnson-Janssen vaccine in the phase 1\/2 trials (n=20) were 5- and 3-fold lower against the B.1.351 (Beta) and P.1 (Gamma) variants, respectively, compared with the wild-type strain on day 71 following vaccination. Binding antibody titers were impaired but to a lesser extent, with a 3-fold reduction against both variants compared to the wild-type strain. By contrast, functional non-neutralizing antibody responses and T-cell responses were largely preserved against the variants.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Alter et al.\u00a0(June 9, 2021). Immunogenicity of Ad26.COV2.S Vaccine against SARS-CoV-2 Variants in Humans. Nature. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03681-2\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41586-021-03681-2<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Median anti-SARS-CoV-2 neutralizing antibody titers of sera from individuals vaccinated with the Johnson &amp; Johnson-Janssen vaccine in the phase 1\/2 trials (n=20) were 5- and 3-fold lower against the B.1.351 (Beta) and P.1 (Gamma) variants, respectively, compared with the wild-type strain on day 71 following vaccination. Binding antibody titers were impaired but to a lesser&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/10\/immunogenicity-of-ad26-cov2-s-vaccine-against-sars-cov-2-variants-in-humans\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,142,159],"topic":[31],"class_list":["post-10313","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-vaccine","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10313"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10313\/revisions"}],"predecessor-version":[{"id":10314,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10313\/revisions\/10314"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10313"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}