{"id":10317,"date":"2021-06-10T10:31:14","date_gmt":"2021-06-10T17:31:14","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10317"},"modified":"2021-06-11T10:32:07","modified_gmt":"2021-06-11T17:32:07","slug":"antibodies-elicited-by-mrna-1273-vaccination-bind-more-broadly-to-the-receptor-binding-domain-than-do-those-from-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/10\/antibodies-elicited-by-mrna-1273-vaccination-bind-more-broadly-to-the-receptor-binding-domain-than-do-those-from-sars-cov-2-infection\/","title":{"rendered":"Antibodies Elicited by mRNA-1273 Vaccination Bind More Broadly to the Receptor Binding Domain than Do Those from SARS-CoV-2 Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Vaccine-elicited anti-SARS-CoV-2 antibodies in individuals fully vaccinated with the Moderna vaccine in phase 1\/2 trials (n=14) were found to target more epitopes within the receptor binding domain (RBD) when compared to individuals with prior infection. Binding of vaccine-elicited antibodies was more broadly distributed across epitopes compared to infection-elicited antibodies within the RBD, which the authors suggest indicates that single mutations in the RBD are less likely to escape neutralizing activity induced by vaccines than by prior infection.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Greaney et al.\u00a0(June 8, 2021). Antibodies Elicited by mRNA-1273 Vaccination Bind More Broadly to the Receptor Binding Domain than Do Those from SARS-CoV-2 Infection. Science Translational Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1126\/scitranslmed.abi9915\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1126\/scitranslmed.abi9915<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vaccine-elicited anti-SARS-CoV-2 antibodies in individuals fully vaccinated with the Moderna vaccine in phase 1\/2 trials (n=14) were found to target more epitopes within the receptor binding domain (RBD) when compared to individuals with prior infection. Binding of vaccine-elicited antibodies was more broadly distributed across epitopes compared to infection-elicited antibodies within the RBD, which the authors&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/10\/antibodies-elicited-by-mrna-1273-vaccination-bind-more-broadly-to-the-receptor-binding-domain-than-do-those-from-sars-cov-2-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,147,159],"topic":[31],"class_list":["post-10317","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-vaccination","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10317"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10317\/revisions"}],"predecessor-version":[{"id":10318,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10317\/revisions\/10318"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10317"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}