{"id":10325,"date":"2021-06-10T10:35:31","date_gmt":"2021-06-10T17:35:31","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10325"},"modified":"2021-06-11T10:36:20","modified_gmt":"2021-06-11T17:36:20","slug":"highly-specific-memory-b-cells-generation-after-the-2nd-dose-of-bnt162b2-vaccine-compensate-for-the-decline-of-serum-antibodies-and-absence-of-mucosal-iga","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/10\/highly-specific-memory-b-cells-generation-after-the-2nd-dose-of-bnt162b2-vaccine-compensate-for-the-decline-of-serum-antibodies-and-absence-of-mucosal-iga\/","title":{"rendered":"Highly-Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> The Pfizer-BioNTech vaccine only elicited a short-lived mucosal IgA antibody response in a study of 108 vaccinated healthcare workers (HCWs) in Italy without prior infection, with none of the vaccinated HCWs tested for mucosal IgA having a detectable response 2-3 weeks after the second dose. By contrast, the vaccine elicited robust memory B cell responses that were highly specific to SARS-COV-2 up to 3 months after the first dose, including IgA-secreting memory B cells.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Mortari et al.\u00a0(June 9, 2021). Highly-Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA. Pre-print downloaded Jun 10 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.06.08.21258284\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.06.08.21258284<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] The Pfizer-BioNTech vaccine only elicited a short-lived mucosal IgA antibody response in a study of 108 vaccinated healthcare workers (HCWs) in Italy without prior infection, with none of the vaccinated HCWs tested for mucosal IgA having a detectable response 2-3 weeks after the second dose. By contrast, the vaccine elicited robust memory&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/10\/highly-specific-memory-b-cells-generation-after-the-2nd-dose-of-bnt162b2-vaccine-compensate-for-the-decline-of-serum-antibodies-and-absence-of-mucosal-iga\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,142],"topic":[31],"class_list":["post-10325","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10325","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10325"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10325\/revisions"}],"predecessor-version":[{"id":10326,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10325\/revisions\/10326"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10325"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10325"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}