{"id":10327,"date":"2021-06-10T10:36:27","date_gmt":"2021-06-10T17:36:27","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10327"},"modified":"2021-06-11T10:37:11","modified_gmt":"2021-06-11T17:37:11","slug":"clinical-and-molecular-characteristics-of-covid-19-patients-with-persistent-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/10\/clinical-and-molecular-characteristics-of-covid-19-patients-with-persistent-sars-cov-2-infection\/","title":{"rendered":"Clinical and Molecular Characteristics of COVID-19 Patients with Persistent SARS-CoV-2 Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">COVID-19 patients with extended viral shedding for &gt;45 days (n=12) had lower levels of inflammatory cytokines\/chemokines (IL-2, TNF, and LT-\u03b1) compared to an age- and sex-matched cohort of COVID-19 patients in whom viral shedding resolved within 21 days (n=39). Single-cell RNA sequencing from peripheral mononuclear blood cells from a subset of patients showed suppressed T cell responses and reduced expression of ribosomal protein genes in patients with extended viral shedding.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Yang et al.\u00a0(June 9, 2021). Clinical and Molecular Characteristics of COVID-19 Patients with Persistent SARS-CoV-2 Infection. Nature Communications. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41467-021-23621-y\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41467-021-23621-y<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>COVID-19 patients with extended viral shedding for &gt;45 days (n=12) had lower levels of inflammatory cytokines\/chemokines (IL-2, TNF, and LT-\u03b1) compared to an age- and sex-matched cohort of COVID-19 patients in whom viral shedding resolved within 21 days (n=39). Single-cell RNA sequencing from peripheral mononuclear blood cells from a subset of patients showed suppressed T&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/10\/clinical-and-molecular-characteristics-of-covid-19-patients-with-persistent-sars-cov-2-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34,51],"topic":[20],"class_list":["post-10327","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","tag-sequelae","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10327"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10327\/revisions"}],"predecessor-version":[{"id":10328,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10327\/revisions\/10328"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10327"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}