{"id":10340,"date":"2021-06-11T11:20:50","date_gmt":"2021-06-11T18:20:50","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10340"},"modified":"2021-06-15T11:33:01","modified_gmt":"2021-06-15T18:33:01","slug":"covid-19-literature-situation-report-june-11-2021","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/11\/covid-19-literature-situation-report-june-11-2021\/","title":{"rendered":"COVID-19 Literature Situation Report June 11, 2021"},"content":{"rendered":"<p>The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.<\/p>\n<p><em>Today&#8217;s summary is based on a review of 308 articles (287\u00a0 published, 21 in preprint)<\/em><\/p>\n<p><strong><a href=\"https:\/\/depts.washington.edu\/pandemicalliance\/wordpress\/wp-content\/uploads\/2021\/06\/LitRep_20210610.docx.pdf\">View the PDF version here.<\/a><\/strong><\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li><b>The incidence of multisystem inflammatory syndrome in children (MIS-C) in the US was 5.1 per 100,000 person-months and 316 per 1,000,000 (0.0003%) SARS-CoV-2 infections, based on a retrospective cohort study of young persons under 21 years of age with SARS-CoV-2 infection diagnosed April-June 2020 in 7 US states that identified 248 cases of (MIS-C). The authors conclude that these results indicate MIS-C was a rare complication associated with SARS-CoV-2 during this time period.<\/b> <a href=\"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.16420\"><span style=\"font-weight: 400\">More<\/span><\/a><\/li>\n<\/ul>\n<ul>\n<li><b>Emergency department visits for suspected suicide attempts were 51% higher among young females aged 12-17 between February 21 and March 20, 2021 compared to the same period in 2019, based on a review of US National Syndromic Surveillance Program data. The observed increase in visits for suicide attempts began in summer 2020 and remained elevated through May 15, 2021. The authors hypothesize that these increased rates may have been affected by COVID-19 pandemic mitigation measures that resulted in a lack of connectedness to schools, teachers, and peers, barriers to mental health treatment, increases in substance use, and anxiety about family health and economic problems. <\/b><a href=\"https:\/\/doi.org\/10.15585\/mmwr.mm7024e1\"><b>More<\/b><\/a><\/li>\n<\/ul>\n<ul>\n<li><b>An <\/b><b><i>in-vitro<\/i><\/b><b> study of sera from persons fully vaccinated with the Pfizer-BioNTech vaccine found that all samples neutralized SARS-CoV-2 virus variants B.1.617.1 (Kappa), B.1.617.2 (Delta), B.1.618 (first identified in India) and B.1.525 (first identified in Nigeria). The authors suggest that these results indicate that vaccination will reduce transmission of existing variants and reduce emergence of new variants. <\/b><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03693-y\"><b>More<\/b><\/a><\/li>\n<\/ul>\n<div id=\"uw-accordion-shortcode\">\n<h3>Article Summaries<\/h3>\n<div class=\"js-accordion\" data-accordion-prefix-classes=\"uw-accordion-shortcode\">\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Geographic Spread<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-10342\" class=\"su-post\">\n<h5 class=\"su-post-title\">SARS-CoV2 Spike Protein Gene Variants with N501T and G142D Mutation-Dominated Infections in Mink in the United States<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">An analysis of SARS-CoV-2 sequences isolated from farmed mink populations (N=977) and human infections in the US and Canada (N=192,806) from December 2019-March 2021 revealed that the N501T mutation was found in humans two months prior to being detected in mink populations. However, in contrast to the N501Y mutation, which is present in the B.1.1.7 (Alpha), B.1.351 (Beta), and P.1 (Gamma) variants and has been associated with higher transmissibility, the N501T mutation was not found to be associated with higher levels of transmission.<\/span> <span style=\"font-weight: 400\">The authors suggest that these results indicate that SARS-CoV-2 variants may have evolved in humans prior to being detected in mink populations.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Cai and Cai. (June 2021). SARS-CoV2 Spike Protein Gene Variants with N501T and G142D Mutation-Dominated Infections in Mink in the United States. Journal of Veterinary Diagnostic Investigation: Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1177\/10406387211023481\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1177\/10406387211023481<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Testing and Treatment<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-10344\" class=\"su-post\">\n<h5 class=\"su-post-title\">Improved Survival among Hospitalized Patients with COVID-19 Treated with Remdesivir and Dexamethasone. A Nationwide Population-Based Cohort Study<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A retrospective cohort study from Denmark found that patients hospitalized with COVID-19 (N=2,747) who were treated with remdesivir and dexamethasone had lower odds of 30-day mortality (OR=0.47) and progression to mechanical ventilation (OR=0.36) compared to persons receiving the standard of care. However, the authors caution that because treatment was not randomized, study data does not permit the distinction between individual effects of the drugs vs. additional interventions during hospitalization on measured outcomes. However, the authors controlled for confounding factors that may have influenced treatment decisions and disease severity by using inverse probability weighted logistic regression.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Benfield et al. (June 2021). Improved Survival among Hospitalized Patients with COVID-19 Treated with Remdesivir and Dexamethasone. A Nationwide Population-Based Cohort Study. Clinical Infectious Diseases. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciab536\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1093\/cid\/ciab536<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\">Vaccines and Immunity<\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-10352\" class=\"su-post\">\n<h5 class=\"su-post-title\">Does Reactogenicity after a Second Injection of the BNT162b2 Vaccine Predict Spike IgG Antibody Levels in Healthy Japanese Subjects<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A small study of Japanese healthcare workers (N=67) found that reactogenicity to a second dose of the Pfizer-BioNTech vaccine was not a predictor of subsequent IgG antibody levels. The study controlled for age, sex, and IgG levels after the first dose of vaccine. The prevalence of local and systemic reactogenicity was 2.5-times higher after the second dose compared to the first dose, with a higher severity in younger persons, and spike IgG titers increased 16-fold after the second dose.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Takeuchi et al. (June 10, 2021). Does Reactogenicity after a Second Injection of the BNT162b2 Vaccine Predict Spike IgG Antibody Levels in Healthy Japanese Subjects. Pre-print downloaded Jun 11 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.06.08.21258444\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.06.08.21258444<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-10350\" class=\"su-post\">\n<h5 class=\"su-post-title\">Symptomatic SARS-CoV-2 Infections After Full Schedule BNT162b2 Vaccination in Seropositive Healthcare Workers: A Case Series From a Single Institution<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Data from a voluntary surveillance program at a single medical center in Italy revealed that 11 healthcare workers who had been fully vaccinated with the Pfizer-BioNTech vaccine had SARS-CoV-2 detected in nasopharyngeal swabs and 5 of these persons had mild symptoms. The average cycle threshold (Ct) in detected infections was 19 (range 6-26). However, no cases of nosocomial transmission were documented from these healthcare workers to patients. <\/span><i><span style=\"font-weight: 400\">[EDITORIAL NOTE: This article did not report the number of vaccinated health care workers from among which the 11 SARS-CoV-2-positive individuals emerged, which makes it impossible to determine the incidence of infection among fully vaccinated individuals.]<\/span><\/i><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Baj et al. (June 10, 2021). Symptomatic SARS-CoV-2 Infections After Full Schedule BNT162b2 Vaccination in Seropositive Healthcare Workers: A Case Series From a Single Institution. Emerging Microbes &amp; Infections. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1080\/22221751.2021.1942230\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1080\/22221751.2021.1942230<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-10348\" class=\"su-post\">\n<h5 class=\"su-post-title\">First-Dose ChAdOx1 and BNT162b2 COVID-19 Vaccines and Thrombocytopenic, Thromboembolic and Hemorrhagic Events in Scotland<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Compared to those who received one dose of the Pfizer-BioNTech COVID-19 vaccine, receipt of one dose of the Oxford-AstraZeneca vaccine was associated with a higher risk of\u00a0idiopathic thrombocytopenic purpura (ITP), a blood disorder involving low platelet counts, during 0\u201327 days after vaccination (adjusted RR = 5.8), with an estimated incidence of 1.13 cases per 100,000 doses. Findings were based on a nested, incident-matched case-control study (N=2.5 million) conducted in Scotland. Confirmatory self-controlled case series analysis confirmed this association was unlikely to be due to bias, although the true risk ratio is likely lower (RR=1.2) due to the potential for overestimation of reported results due to residual confounding. Receipt of the Pfizer-BioNTech vaccine was not associated with ITP. The authors suggest that using an alternative to the AstraZeneca vaccines may be appropriate for individuals at low risk of COVID-19 if supply allows.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Simpson et al. (June 2021). First-Dose ChAdOx1 and BNT162b2 COVID-19 Vaccines and Thrombocytopenic, Thromboembolic and Hemorrhagic Events in Scotland. Nature Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41591-021-01408-4\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41591-021-01408-4<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-10346\" class=\"su-post\">\n<h5 class=\"su-post-title\">BNT162b2-Elicited Neutralization of B.1.617 and Other SARS-CoV-2 Variants<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">An <\/span><i><span style=\"font-weight: 400\">in-vitro<\/span><\/i><span style=\"font-weight: 400\"> study of sera from persons fully vaccinated with the Pfizer-BioNTech vaccine found that all samples neutralized SARS-CoV-2 virus variants B.1.617.1 (Kappa), B.1.617.2 (Delta), B.1.618 (first identified in India) and B.1.525 (Eta, first identified in Nigeria). Neutralization of all variants, with the exception of B.1.617.1, was only slightly reduced compared to neutralization of wild-type SARS-CoV-2. Although neutralization of B.1.617.1 was somewhat reduced, the sera still neutralized this variant. The authors suggest that vaccination will reduce transmission of existing variants and reduce emergence of new variants.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Liu et al. (June 2021). BNT162b2-Elicited Neutralization of B.1.617 and Other SARS-CoV-2 Variants. Nature. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03693-y\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41586-021-03693-y<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Clinical Characteristics and Health Care Setting<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-10356\" class=\"su-post\">\n<h5 class=\"su-post-title\">Dynamic Changes in the Immune Response Correlate with Disease Severity and Outcomes During Infection with SARS-CoV-2<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A small, single center study of persons hospitalized with COVID-19 in China (N=74) identified innate and adaptive immunological differences between patients with severe and non-severe disease. Specifically, patients with severe disease had lower baseline lymphocyte counts, higher neutrophil to lymphocyte ratios, and lower eosinophil counts. T-cell, B-cell, and natural killer cells were also lower among those with severe disease. The authors suggest that these results indicate that innate and adaptive immune responses are correlated with COVID-19 disease severity.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Zheng et al. (June 2021). Dynamic Changes in the Immune Response Correlate with Disease Severity and Outcomes During Infection with SARS-CoV-2. Infectious Diseases and Therapy. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1007\/s40121-021-00458-y\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1007\/s40121-021-00458-y<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<div id=\"su-post-10354\" class=\"su-post\">\n<h5 class=\"su-post-title\">Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A retrospective cohort study of persons with SARS-CoV-2 infection diagnosed between April and June 2020 in 7 US states identified 248 cases of multisystem inflammatory syndrome in children (MIS-C) in persons &lt;21 years of age. The corresponding incidence of MIS-C was 5.1 per 100,000 person-months and 316 persons per 1,000,000 (0.0003%) SARS-CoV-2 infections. Incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons compared to white persons and lower among those aged 16-20 compared to children &lt;5 years of age. The authors indicate that MIS-C was a rare complication associated with SARS-CoV-2 during this time period and suggest that the study can serve as a baseline for monitoring of MIS-C after increased vaccination uptake.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Payne et al. (June 2021). Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Network Open. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.16420\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.16420<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Mental Health and Personal Impact<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-10358\" class=\"su-post\">\n<h5 class=\"su-post-title\">Emergency Department Visits for Suspected Suicide Attempts Among Persons Aged 12\u201325 Years Before and During the COVID-19 Pandemic \u2014 United States, January 2019\u2013May 2021<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Emergency department visits for suspected suicide attempts were 51% higher among young females aged 12-17 between February 21 and March 20, 2021 compared to the same period in 2019, according to a review of US National Syndromic Surveillance Program data. Among young males of the same age, emergency department visits for suicide attempt were up 4%. The observed increase in visits for suicide attempts began in summer 2020 and remained elevated through May 15, 2021. The authors hypothesize that these increased rates may have been affected by COVID-9 pandemic mitigation measures, resulting in a lack of connectedness to schools, teachers, and peers, barriers to mental health treatment, increases in substance use, and anxiety about family health and economic problems, which are all risk factors for suicide.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Yard et al. (June 11, 2021). Emergency Department Visits for Suspected Suicide Attempts Among Persons Aged 12\u201325 Years Before and During the COVID-19 Pandemic \u2014 United States, January 2019\u2013May 2021. MMWR. <\/span><\/i><a href=\"https:\/\/doi.org\/10.15585\/mmwr.mm7024e1\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.15585\/mmwr.mm7024e1<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"js-accordion__panel\" >\n<h2 class=\"js-accordion__header\"><span style=\"font-weight: 400\">Public Health Policy and Practice<\/span><\/h2>\n<div class=\"su-posts su-posts-default-loop\">\n<div id=\"su-post-10360\" class=\"su-post\">\n<h5 class=\"su-post-title\">Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies in the Staff of a Public School System in the Midwestern United States<\/h5>\n<p>\t\t\t\t<!-- \n\n\n\n\n\n\n\n\n\n\n\n<div class=\"su-post-meta\">\n\t\t\t\t\t: \t\t\t\t<\/div>\n\n\n\n\n\n\n\n\n\n\n\n --><\/p>\n<div class=\"su-post-excerpt\">\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A cross-sectional seroprevalence survey of teachers and staff (N=753) at a school in suburban Indiana conducted in July 2020 found that 1.7% of tested persons had antibodies to SARS-CoV-2. Persons with a previously confirmed SARS-CoV-2 infection had 48-fold higher odds of seropositivity compared to persons without previous infection, controlling for mask usage, travel history, symptom history, and known contact with persons with confirmed infection. In persons without previous infection, exposure to a person with confirmed infection was associated with 7-fold higher odds of seropositivity.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Lopez et al. (2021). Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies in the Staff of a Public School System in the Midwestern United States. PloS One. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0243676\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1371\/journal.pone.0243676<\/span><\/a><\/p>\n<\/p>\n<\/div>\n<p>\t\t\t\t\t\t\t\t\t<!-- <a href=\"\" class=\"su-post-comments-link\"><\/a> --><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2>Other Resources and Commentaries<\/h2>\n<ul>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1101\/2021.06.08.21258421\"><span style=\"font-weight: 400\">Wastewater-Based Epidemiology for Tracking COVID-19 Trend and Variants of Concern in Ohio United States<\/span><\/a><span style=\"font-weight: 400\"> \u2013 MedRxiv (June 10)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1093\/pubmed\/fdab201\"><span style=\"font-weight: 400\">Changing the COVID-19 Vaccine Narrative to Dispel Vaccine Hesitancy<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Journal of Public Health (Oxford, England) (June)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2021.105906\"><span style=\"font-weight: 400\">Cerebral Venous Thrombosis after BNT162b2 MRNA SARS-CoV-2 Vaccine<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Journal of Stroke and Cerebrovascular Diseases\u00a0: The Official Journal of National Stroke Association (May)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.2471\/BLT.20.276782\"><span style=\"font-weight: 400\">COVID-19-Related Misinformation on Social Media: A Systematic Review<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Bulletin of the World Health Organization (June)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1038\/s41564-021-00932-w\"><span style=\"font-weight: 400\">SARS-CoV-2 Variants of Interest and Concern Naming Scheme Conducive for Global Discourse<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Nature Microbiology (June 9)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.2105\/AJPH.2021.306263\"><span style=\"font-weight: 400\">Incorporating Health Equity Into COVID-19 Reopening Plans: Policy Experimentation in California<\/span><\/a><span style=\"font-weight: 400\"> \u2013 American Journal of Public Health (June)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1038\/d41586-021-01540-8\"><span style=\"font-weight: 400\">How a Rampant Coronavirus Variant Blunts Our Immune Defences<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Nature (June 9)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1016\/j.addbeh.2021.107003\"><span style=\"font-weight: 400\">Factors Associated with Alcohol and Tobacco Consumption as a Coping Strategy to Deal with the Coronavirus Disease (COVID-19) Pandemic and Lockdown in Spain<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Addictive Behaviors (Oct)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1016\/j.cmi.2021.06.001\"><span style=\"font-weight: 400\">The Interface between COVID-19 and Bacterial Healthcare-Associated Infections<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Clinical Microbiology and Infection (June)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1016\/j.eclinm.2021.100928\"><span style=\"font-weight: 400\">Initial Observations on Age, Gender, BMI and Hypertension in Antibody Responses to SARS-CoV-2 BNT162b2 Vaccine<\/span><\/a><span style=\"font-weight: 400\"> \u2013 EClinicalMedicine (June)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1016\/j.watres.2021.117090\"><span style=\"font-weight: 400\">Decay of Infectious SARS-CoV-2 and Surrogates in Aquatic Environments<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Water Research (Mar)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciab537\"><span style=\"font-weight: 400\">Use of U.S. Blood Donors for National Serosurveillance of SARS-CoV-2 Antibodies: Basis for an Expanded National Donor Serosurveillance Program<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Clinical Infectious Diseases (June 10)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.2105\/AJPH.2021.306340\"><span style=\"font-weight: 400\">Excess Deaths Reveal the Substantial Impact of COVID-19 Pandemic on Mortality in the State of Florida<\/span><\/a><span style=\"font-weight: 400\"> \u2013 American Journal of Public Health (June 10)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1101\/2021.06.08.21258434\"><span style=\"font-weight: 400\">The Impact of COVID-19 Pandemic on Influenza Transmission Molecular and Epidemiological Evidence<\/span><\/a><span style=\"font-weight: 400\"> \u2013 MedRxiv (June 10)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1001\/jamaoncol.2021.1962\"><span style=\"font-weight: 400\">Attitudes and Factors Associated With COVID-19 Vaccine Hesitancy Among Patients With Breast Cancer<\/span><\/a><span style=\"font-weight: 400\"> \u2013 JAMA Oncology (June)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1038\/d41586-021-01508-8\"><span style=\"font-weight: 400\">Embrace the WHO\u2019s New Naming System for Coronavirus Variants<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Nature (June 10)<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/doi.org\/10.1038\/d41586-021-01510-0\"><span style=\"font-weight: 400\">COVID Nasal Spray, Dark-Matter Map and a Variant\u2019s Rise<\/span><\/a><span style=\"font-weight: 400\"> \u2013 Nature (June 10)<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><i><span style=\"font-weight: 400\">Report prepared by the UW Alliance for Pandemic Preparedness and Global Health Security and the START Center in collaboration with and on behalf of WA DOH COVID-19 Incident Management Team<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The incidence of multisystem inflammatory syndrome in children (MIS-C) in the US was 5.1 per 100,000 person-months and 316 per 1,000,000 (0.0003%) SARS-CoV-2 infections, based on a retrospective cohort study of young persons under 21 years of age with SARS-CoV-2 infection diagnosed April-June 2020 in 7 US states that identified 248 cases of (MIS-C). The authors conclude that these results indicate MIS-C was a rare complication associated with SARS-CoV-2 during this time period. <\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/11\/seroprevalence-of-anti-sars-cov-2-igg-antibodies-in-the-staff-of-a-public-school-system-in-the-midwestern-united-states\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":8810,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[5],"tags":[],"topic":[],"class_list":["post-10340","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19-literature-situation-report"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10340"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10340\/revisions"}],"predecessor-version":[{"id":10362,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10340\/revisions\/10362"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media\/8810"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10340"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}