{"id":10356,"date":"2021-06-11T11:29:54","date_gmt":"2021-06-11T18:29:54","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10356"},"modified":"2021-06-15T11:30:32","modified_gmt":"2021-06-15T18:30:32","slug":"dynamic-changes-in-the-immune-response-correlate-with-disease-severity-and-outcomes-during-infection-with-sars-cov-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/11\/dynamic-changes-in-the-immune-response-correlate-with-disease-severity-and-outcomes-during-infection-with-sars-cov-2\/","title":{"rendered":"Dynamic Changes in the Immune Response Correlate with Disease Severity and Outcomes During Infection with SARS-CoV-2"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A small, single center study of persons hospitalized with COVID-19 in China (N=74) identified innate and adaptive immunological differences between patients with severe and non-severe disease. Specifically, patients with severe disease had lower baseline lymphocyte counts, higher neutrophil to lymphocyte ratios, and lower eosinophil counts. T-cell, B-cell, and natural killer cells were also lower among those with severe disease. The authors suggest that these results indicate that innate and adaptive immune responses are correlated with COVID-19 disease severity.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Zheng et al. (June 2021). Dynamic Changes in the Immune Response Correlate with Disease Severity and Outcomes During Infection with SARS-CoV-2. Infectious Diseases and Therapy. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1007\/s40121-021-00458-y\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1007\/s40121-021-00458-y<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A small, single center study of persons hospitalized with COVID-19 in China (N=74) identified innate and adaptive immunological differences between patients with severe and non-severe disease. Specifically, patients with severe disease had lower baseline lymphocyte counts, higher neutrophil to lymphocyte ratios, and lower eosinophil counts. T-cell, B-cell, and natural killer cells were also lower among&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/11\/dynamic-changes-in-the-immune-response-correlate-with-disease-severity-and-outcomes-during-infection-with-sars-cov-2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[201],"topic":[20],"class_list":["post-10356","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immune-response","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10356","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10356"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10356\/revisions"}],"predecessor-version":[{"id":10357,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10356\/revisions\/10357"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10356"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10356"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10356"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10356"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}