{"id":10397,"date":"2021-06-15T08:56:51","date_gmt":"2021-06-15T15:56:51","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10397"},"modified":"2021-06-16T08:57:50","modified_gmt":"2021-06-16T15:57:50","slug":"rapidly-emerging-sars-cov-2-b-1-1-7-sub-lineage-in-the-united-states-of-america-with-spike-protein-d178h-and-membrane-protein-v70l-mutations-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/15\/rapidly-emerging-sars-cov-2-b-1-1-7-sub-lineage-in-the-united-states-of-america-with-spike-protein-d178h-and-membrane-protein-v70l-mutations-2\/","title":{"rendered":"Rapidly Emerging SARS-CoV-2 B.1.1.7 Sub-Lineage in the United States of America with Spike Protein D178H and Membrane Protein V70L Mutations"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Genomic surveillance of SARS-CoV-2 cases identified an expanding US-specific sub-lineage of the B.1.1.7 (Alpha) variant. This sub-lineage is characterized with sequential acquisition of a membrane protein mutation, V20L, in November 2020 and a spike mutation, D178H, in early February 2021. The proportion of B.1.1.7 (Alpha) isolates in the US belonging to this sub-lineage increased from 0.15% in February to 1.8% in April 2021. The sub-lineage comprises 37% of B.1.1.7 (Alpha) isolates in Washington State to date and has also been detected in 30 other states. Phylogenetic analysis suggests the sub-lineage may have originated from either California or Washington, while structural analysis suggests the D178H mutation may affect neutralization capacity of antibodies targeting the N terminal domain. <\/span><i><span style=\"font-weight: 400\">[EDITORIAL NOTE: A pre-print version of this article was summarized in this report on May 19, 2021.]<\/span><\/i><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Shen et al.\u00a0(June 14, 2021). Rapidly Emerging SARS-CoV-2 B.1.1.7 Sub-Lineage in the United States of America with Spike Protein D178H and Membrane Protein V70L Mutations. Emerging Microbes &amp; Infections. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1080\/22221751.2021.1943540\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1080\/22221751.2021.1943540<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genomic surveillance of SARS-CoV-2 cases identified an expanding US-specific sub-lineage of the B.1.1.7 (Alpha) variant. This sub-lineage is characterized with sequential acquisition of a membrane protein mutation, V20L, in November 2020 and a spike mutation, D178H, in early February 2021. The proportion of B.1.1.7 (Alpha) isolates in the US belonging to this sub-lineage increased from&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/15\/rapidly-emerging-sars-cov-2-b-1-1-7-sub-lineage-in-the-united-states-of-america-with-spike-protein-d178h-and-membrane-protein-v70l-mutations-2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[40,159],"topic":[24],"class_list":["post-10397","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-geographic-spread","tag-variants","topic-geographic-spread"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10397"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10397\/revisions"}],"predecessor-version":[{"id":10398,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10397\/revisions\/10398"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10397"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}