{"id":10405,"date":"2021-06-15T09:01:06","date_gmt":"2021-06-15T16:01:06","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10405"},"modified":"2021-06-16T09:02:13","modified_gmt":"2021-06-16T16:02:13","slug":"young-infants-exhibit-robust-functional-antibody-responses-and-restrained-ifn-%ce%b3-production-to-sars-cov-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/15\/young-infants-exhibit-robust-functional-antibody-responses-and-restrained-ifn-%ce%b3-production-to-sars-cov-2\/","title":{"rendered":"Young Infants Exhibit Robust Functional Antibody Responses and Restrained IFN-\u03b3 Production to SARS-CoV-2"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A study evaluating the immune responses in four infants with mild COVID-19 (median age 7 weeks old) found that compared to their parents who also had COVID-19 (n=8) and a cohort of adult controls with prior COVID-19 (n=10), infants had higher anti-SARS-CoV-2 IgG antibody levels in both sera and saliva and exhibited more robust serum neutralizing activity. Infants also had reduced production of interferon-gamma after direct <\/span><i><span style=\"font-weight: 400\">ex-vivo<\/span><\/i><span style=\"font-weight: 400\"> stimulation (ELISPOT), despite a comparable frequency of SARS-specific T cells and comparable capacity for expansion with prolonged stimulation with SARS-CoV-2 antigens.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Goenka et al.\u00a0(June 9, 2021). Young Infants Exhibit Robust Functional Antibody Responses and Restrained IFN-\u03b3 Production to SARS-CoV-2. Cell Reports Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.xcrm.2021.100327\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.xcrm.2021.100327<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study evaluating the immune responses in four infants with mild COVID-19 (median age 7 weeks old) found that compared to their parents who also had COVID-19 (n=8) and a cohort of adult controls with prior COVID-19 (n=10), infants had higher anti-SARS-CoV-2 IgG antibody levels in both sera and saliva and exhibited more robust serum&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/15\/young-infants-exhibit-robust-functional-antibody-responses-and-restrained-ifn-%ce%b3-production-to-sars-cov-2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,32,215],"topic":[31],"class_list":["post-10405","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-immunity","tag-infants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10405"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10405\/revisions"}],"predecessor-version":[{"id":10406,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10405\/revisions\/10406"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10405"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}