{"id":10411,"date":"2021-06-15T09:04:40","date_gmt":"2021-06-15T16:04:40","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=10411"},"modified":"2021-06-16T09:05:40","modified_gmt":"2021-06-16T16:05:40","slug":"naturally-enhanced-neutralizing-breadth-against-sars-cov-2-one-year-after-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/15\/naturally-enhanced-neutralizing-breadth-against-sars-cov-2-one-year-after-infection\/","title":{"rendered":"Naturally Enhanced Neutralizing Breadth against SARS-CoV-2 One Year after Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">82% of individuals recovered from COVID-19 maintained RBD-specific IgG titers, RBD-specific B cells, and neutralizing activities between 6-12 months after infection, according to analysis of 68 recovered individuals, suggesting long-lived immunity to COVID-19. In 41% of participants who received an mRNA vaccine, vaccination increased IgG responses by 30-fold, neutralizing activity by 50-fold, and circulating number of memory B cells by 9-fold. Sera from vaccinated individuals also showed robust neutralizing activity against variants of concern and neutralization breadth (the ability to neutralize a diverse panel of viruses) increased over time.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Wang et al.\u00a0(June 14, 2021). Naturally Enhanced Neutralizing Breadth against SARS-CoV-2 One Year after Infection. Nature. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03696-9\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41586-021-03696-9<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>82% of individuals recovered from COVID-19 maintained RBD-specific IgG titers, RBD-specific B cells, and neutralizing activities between 6-12 months after infection, according to analysis of 68 recovered individuals, suggesting long-lived immunity to COVID-19. In 41% of participants who received an mRNA vaccine, vaccination increased IgG responses by 30-fold, neutralizing activity by 50-fold, and circulating number&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/06\/15\/naturally-enhanced-neutralizing-breadth-against-sars-cov-2-one-year-after-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[230,33],"topic":[31],"class_list":["post-10411","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine-effectiveness","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=10411"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10411\/revisions"}],"predecessor-version":[{"id":10412,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/10411\/revisions\/10412"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=10411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=10411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=10411"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=10411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}