{"id":1052,"date":"2020-09-22T11:43:47","date_gmt":"2020-09-22T18:43:47","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1052"},"modified":"2020-09-23T11:44:42","modified_gmt":"2020-09-23T18:44:42","slug":"a-prospective-randomized-open-label-trial-of-early-versus-late-favipiravir-in-hospitalized-patients-with-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/22\/a-prospective-randomized-open-label-trial-of-early-versus-late-favipiravir-in-hospitalized-patients-with-covid-19\/","title":{"rendered":"A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir in Hospitalized Patients with COVID-19"},"content":{"rendered":"<ul>\n<li>There was no significant difference in the rate of SARS-CoV-2 viral clearance between patients receiving early treatment with the anti-viral agent favipiravir and those receiving late treatment in a prospective, randomized, open-label, multicenter trial at 25 hospitals across Japan (aHR=1.42; 95%CI 0.76\u20132.62). Favipiravir did not significantly improve viral clearance as measured by RT-PCR by day 6, but was associated with a shorter fever duration. The most common adverse event associated with favipiravir was elevated serum uric acid, which occurred in 84% of participants and was transient. No patients experienced progression of disease or death.<\/li>\n<\/ul>\n<p>Doi et al. (Sept 21, 2020). A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir in Hospitalized Patients with COVID-19. Antimicrobial Agents and Chemotherapy. <a href=\"https:\/\/doi.org\/10.1128\/AAC.01897-20\">https:\/\/doi.org\/10.1128\/AAC.01897-20<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>There was no significant difference in the rate of SARS-CoV-2 viral clearance between patients receiving early treatment with the anti-viral agent favipiravir and those receiving late treatment in a prospective, randomized, open-label, multicenter trial at 25 hospitals across Japan (aHR=1.42; 95%CI 0.76\u20132.62). Favipiravir did not significantly improve viral clearance as measured by RT-PCR by day&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/22\/a-prospective-randomized-open-label-trial-of-early-versus-late-favipiravir-in-hospitalized-patients-with-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-1052","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1052"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1052\/revisions"}],"predecessor-version":[{"id":1053,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1052\/revisions\/1053"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1052"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}