{"id":1054,"date":"2020-09-22T11:45:01","date_gmt":"2020-09-22T18:45:01","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1054"},"modified":"2020-09-23T11:53:48","modified_gmt":"2020-09-23T18:53:48","slug":"kinetics-of-sars-cov-2-specific-antibodies-igm-iga-igg-in-non-hospitalized-patients-four-months-following-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/22\/kinetics-of-sars-cov-2-specific-antibodies-igm-iga-igg-in-non-hospitalized-patients-four-months-following-infection\/","title":{"rendered":"Kinetics of SARS-CoV-2 Specific Antibodies (IgM, IgA, IgG) in Non-Hospitalized Patients Four Months Following Infection"},"content":{"rendered":"<ul>\n<li>Levels of antibodies against SARS-CoV-2 were found to decline over an 18-week period following symptom onset, although antibodies remained detectable. Data from longitudinal profiles of different antibody immunoglobulin classes using tests with different antigens and neutralizing titers showed that receptor-binding-domain-specific (RBD) and nucleocapsid protein-specific (NCP) IgM as well as S1-specific IgA levels significantly decreased within four months after COVID-19 onset, with RBD-specific IgM and S1-specific IgA still detectable at this time point. Furthermore, the authors reported a stronger decrease for NCP- than for S1-specific IgG antibodies and neutralizing titers, suggesting that the observed durability of SARS-CoV-2 antibody responses depends on the tests used for their assessment.<\/li>\n<\/ul>\n<p>Orth-H\u00f6ller et al. (Sept 18, 2020). Kinetics of SARS-CoV-2 Specific Antibodies (IgM, IgA, IgG) in Non-Hospitalized Patients Four Months Following Infection. Journal of Infection. <a href=\"https:\/\/doi.org\/10.1016\/j.jinf.2020.09.015\">https:\/\/doi.org\/10.1016\/j.jinf.2020.09.015<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Levels of antibodies against SARS-CoV-2 were found to decline over an 18-week period following symptom onset, although antibodies remained detectable. Data from longitudinal profiles of different antibody immunoglobulin classes using tests with different antigens and neutralizing titers showed that receptor-binding-domain-specific (RBD) and nucleocapsid protein-specific (NCP) IgM as well as S1-specific IgA levels significantly decreased within&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/22\/kinetics-of-sars-cov-2-specific-antibodies-igm-iga-igg-in-non-hospitalized-patients-four-months-following-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,27],"topic":[19],"class_list":["post-1054","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-testing","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1054"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1054\/revisions"}],"predecessor-version":[{"id":1055,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1054\/revisions\/1055"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1054"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}