{"id":1228,"date":"2020-09-29T09:21:49","date_gmt":"2020-09-29T16:21:49","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1228"},"modified":"2020-09-30T09:23:34","modified_gmt":"2020-09-30T16:23:34","slug":"viral-presence-and-immunopathology-in-patients-with-lethal-covid-19-a-prospective-autopsy-cohort-study","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/29\/viral-presence-and-immunopathology-in-patients-with-lethal-covid-19-a-prospective-autopsy-cohort-study\/","title":{"rendered":"Viral Presence and Immunopathology in Patients with Lethal COVID-19: A Prospective Autopsy Cohort Study"},"content":{"rendered":"<ul>\n<li>An autopsy study among 21 patients who died of COVID-19 showed widespread systemic inflammation in the lungs, heart, kidney, liver, and brain, with a continued presence of inflammatory neutrophils cells even several weeks into the disease course. The lung was the organ with the most abundant SARS-CoV-2, and extensive inflammation was detected in the brain. SARS-CoV-2-infected cells were sporadically present up to 6 weeks after the onset of symptoms, and occasionally found at late stages of COVID-19. The authors note that these findings suggest a maladaptive immune response to SARS-CoV-2.<\/li>\n<\/ul>\n<p>Schurink et al. (Sept 2020). Viral Presence and Immunopathology in Patients with Lethal COVID-19: A Prospective Autopsy Cohort Study. The Lancet Microbe. <a href=\"https:\/\/doi.org\/10.1016\/S2666-5247(20)30144-0\">https:\/\/doi.org\/10.1016\/S2666-5247(20)30144-0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An autopsy study among 21 patients who died of COVID-19 showed widespread systemic inflammation in the lungs, heart, kidney, liver, and brain, with a continued presence of inflammatory neutrophils cells even several weeks into the disease course. The lung was the organ with the most abundant SARS-CoV-2, and extensive inflammation was detected in the brain&#8230;.<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/29\/viral-presence-and-immunopathology-in-patients-with-lethal-covid-19-a-prospective-autopsy-cohort-study\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34],"topic":[20],"class_list":["post-1228","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1228"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1228\/revisions"}],"predecessor-version":[{"id":1229,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1228\/revisions\/1229"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1228"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}