{"id":1241,"date":"2020-09-30T10:01:25","date_gmt":"2020-09-30T17:01:25","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1241"},"modified":"2020-10-01T10:03:36","modified_gmt":"2020-10-01T17:03:36","slug":"efficacy-and-safety-of-hydroxychloroquine-vs-placebo-for-pre-exposure-sars-cov-2-prophylaxis-among-health-care-workers","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/30\/efficacy-and-safety-of-hydroxychloroquine-vs-placebo-for-pre-exposure-sars-cov-2-prophylaxis-among-health-care-workers\/","title":{"rendered":"Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-Exposure SARS-CoV-2 Prophylaxis Among Health Care Workers"},"content":{"rendered":"<ul>\n<li>Daily administration of hydroxychloroquine to hospital-based healthcare workers as pre-exposure prophylaxis against SARS-CoV-2 infection did not change infection risk between participants receiving hydroxychloroquine vs placebo (6.3% vs 6.6%, p&gt;0.99) in this randomized, double-blind, placebo-controlled trial (n=132).<\/li>\n<li>The trial was terminated early due to futility and may have been underpowered to detect clinically important differences.<\/li>\n<\/ul>\n<p>Abella et al. (Sept 30, 2020). Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-Exposure SARS-CoV-2 Prophylaxis Among Health Care Workers. JAMA Internal Medicine. <a href=\"https:\/\/doi.org\/10.1001\/jamainternmed.2020.6319\">https:\/\/doi.org\/10.1001\/jamainternmed.2020.6319<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Daily administration of hydroxychloroquine to hospital-based healthcare workers as pre-exposure prophylaxis against SARS-CoV-2 infection did not change infection risk between participants receiving hydroxychloroquine vs placebo (6.3% vs 6.6%, p&gt;0.99) in this randomized, double-blind, placebo-controlled trial (n=132). The trial was terminated early due to futility and may have been underpowered to detect clinically important differences. Abella&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/09\/30\/efficacy-and-safety-of-hydroxychloroquine-vs-placebo-for-pre-exposure-sars-cov-2-prophylaxis-among-health-care-workers\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[25,75,76,28],"topic":[19],"class_list":["post-1241","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-candidate","tag-report","tag-summarize","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1241"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1241\/revisions"}],"predecessor-version":[{"id":1242,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1241\/revisions\/1242"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1241"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}