{"id":1278,"date":"2020-10-01T09:22:07","date_gmt":"2020-10-01T16:22:07","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1278"},"modified":"2020-10-02T09:23:12","modified_gmt":"2020-10-02T16:23:12","slug":"expression-of-sars-cov-2-entry-receptors-in-the-respiratory-tract-of-healthy-individuals-smokers-and-asthmatics","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/01\/expression-of-sars-cov-2-entry-receptors-in-the-respiratory-tract-of-healthy-individuals-smokers-and-asthmatics\/","title":{"rendered":"Expression of SARS-CoV-2 Entry Receptors in the Respiratory Tract of Healthy Individuals, Smokers and Asthmatics"},"content":{"rendered":"<ul>\n<li>Using publicly available microarray datasets, Matusiak and Sch\u00fcrch reported different protein expression of SARS-CoV-2 entry receptors and cofactors ACE2,\u00a0TMPRSS2,\u00a0BSG (CD147)\u00a0and\u00a0FURIN among various airway tissue types between smokers vs. non-smokers, and between people with asthma vs. healthy controls. These findings warrant further studies to use larger numbers of samples from multiple donor cohorts and more antibodies to better delineate the cellular subsets expressing these SARS-CoV-2 entry receptors and cofactors.<\/li>\n<\/ul>\n<p>Matusiak and Sch\u00fcrch. (Sept 29, 2020). Expression of SARS-CoV-2 Entry Receptors in the Respiratory Tract of Healthy Individuals, Smokers and Asthmatics. Respiratory Research. <a href=\"https:\/\/doi.org\/10.1186\/s12931-020-01521-x\">https:\/\/doi.org\/10.1186\/s12931-020-01521-x<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using publicly available microarray datasets, Matusiak and Sch\u00fcrch reported different protein expression of SARS-CoV-2 entry receptors and cofactors ACE2,\u00a0TMPRSS2,\u00a0BSG (CD147)\u00a0and\u00a0FURIN among various airway tissue types between smokers vs. non-smokers, and between people with asthma vs. healthy controls. These findings warrant further studies to use larger numbers of samples from multiple donor cohorts and more antibodies&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/01\/expression-of-sars-cov-2-entry-receptors-in-the-respiratory-tract-of-healthy-individuals-smokers-and-asthmatics\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34],"topic":[20],"class_list":["post-1278","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1278"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1278\/revisions"}],"predecessor-version":[{"id":1279,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1278\/revisions\/1279"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1278"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}