{"id":1374,"date":"2020-10-06T09:11:18","date_gmt":"2020-10-06T16:11:18","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1374"},"modified":"2020-10-08T09:11:58","modified_gmt":"2020-10-08T16:11:58","slug":"lopinavir-ritonavir-in-patients-admitted-to-hospital-with-covid-19-recovery-a-randomised-controlled-open-label-platform-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/06\/lopinavir-ritonavir-in-patients-admitted-to-hospital-with-covid-19-recovery-a-randomised-controlled-open-label-platform-trial\/","title":{"rendered":"Lopinavir\u2013Ritonavir in Patients Admitted to Hospital with COVID-19 (RECOVERY): A Randomised, Controlled, Open-Label, Platform Trial"},"content":{"rendered":"<ul>\n<li>A randomized open-label trial (RECOVERY trial) found that among patients admitted to hospital with COVID-19, treatment with lopinavir-ritonavir was not associated with reduction in 28-day all-cause mortality (RR=1.03, 95%CI: 0.91-1.17), duration of hospital stay (RR=0.98, 95%CI: 0.91-1.05), or progression to mechanical ventilation or death (RR=1.09, 95%CI: 0.99-1.20). 23% of patients receiving lopinavir-ritonavir died within 28 days, while 22% of patients receiving usual care died within 28 days. Results were consistent across patient subgroups.<\/li>\n<\/ul>\n<p>Horby et al. (Oct 5, 2020). Lopinavir\u2013Ritonavir in Patients Admitted to Hospital with COVID-19 (RECOVERY): A Randomised, Controlled, Open-Label, Platform Trial. The Lancet. <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)32013-4\">https:\/\/doi.org\/10.1016\/S0140-6736(20)32013-4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A randomized open-label trial (RECOVERY trial) found that among patients admitted to hospital with COVID-19, treatment with lopinavir-ritonavir was not associated with reduction in 28-day all-cause mortality (RR=1.03, 95%CI: 0.91-1.17), duration of hospital stay (RR=0.98, 95%CI: 0.91-1.05), or progression to mechanical ventilation or death (RR=1.09, 95%CI: 0.99-1.20). 23% of patients receiving lopinavir-ritonavir died within 28&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/06\/lopinavir-ritonavir-in-patients-admitted-to-hospital-with-covid-19-recovery-a-randomised-controlled-open-label-platform-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-1374","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1374"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1374\/revisions"}],"predecessor-version":[{"id":1375,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1374\/revisions\/1375"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1374"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}