{"id":1376,"date":"2020-10-06T09:12:32","date_gmt":"2020-10-06T16:12:32","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1376"},"modified":"2020-10-08T09:13:16","modified_gmt":"2020-10-08T16:13:16","slug":"temporal-analysis-of-covid-19-convalescent-plasma-donations-reveals-significant-decrease-in-neutralizing-capacity-over-time","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/06\/temporal-analysis-of-covid-19-convalescent-plasma-donations-reveals-significant-decrease-in-neutralizing-capacity-over-time\/","title":{"rendered":"Temporal Analysis of COVID-19 Convalescent Plasma Donations Reveals Significant Decrease in Neutralizing Capacity Over Time"},"content":{"rendered":"<ul>\n<li>[Pre-print, not peer reviewed] Analysis of 981 COVID-19 convalescent plasma (CP) samples from 196 donors shows that over time, neutralizing capacities of CP can decrease below recommended FDA levels of 50% neutralization (PRNT<sub>50%<\/sub>) and 90% neutralization (PPRNT<sub>90%<\/sub>). The most significant decreases of PRNT<sub>50%<\/sub> titer occurred at more than 43 days post initial donation, suggesting a 6-week window may be optimal for collecting therapeutically effective CP.<\/li>\n<\/ul>\n<p>Girardin et al. (Oct 6, 2020). Temporal Analysis of COVID-19 Convalescent Plasma Donations Reveals Significant Decrease in Neutralizing Capacity Over Time. Pre-print downloaded Oct 6 from <a href=\"https:\/\/doi.org\/10.1101\/2020.10.04.20206011\">https:\/\/doi.org\/10.1101\/2020.10.04.20206011<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer reviewed] Analysis of 981 COVID-19 convalescent plasma (CP) samples from 196 donors shows that over time, neutralizing capacities of CP can decrease below recommended FDA levels of 50% neutralization (PRNT50%) and 90% neutralization (PPRNT90%). The most significant decreases of PRNT50% titer occurred at more than 43 days post initial donation, suggesting a&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/06\/temporal-analysis-of-covid-19-convalescent-plasma-donations-reveals-significant-decrease-in-neutralizing-capacity-over-time\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-1376","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1376"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1376\/revisions"}],"predecessor-version":[{"id":1377,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1376\/revisions\/1377"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1376"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}