{"id":1640,"date":"2020-10-19T13:58:33","date_gmt":"2020-10-19T20:58:33","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1640"},"modified":"2020-10-20T14:00:15","modified_gmt":"2020-10-20T21:00:15","slug":"hydroxychloroquine-as-pre-exposure-prophylaxis-for-covid-19-in-healthcare-workers-a-randomized-trial-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/19\/hydroxychloroquine-as-pre-exposure-prophylaxis-for-covid-19-in-healthcare-workers-a-randomized-trial-2\/","title":{"rendered":"Hydroxychloroquine as Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers: A Randomized Trial"},"content":{"rendered":"<p>Pre-exposure prophylaxis with hydroxychloroquine once or twice weekly did not significantly reduce COVID-19 or COVID-19-compatible illness among healthcare workers with ongoing exposure to people with SARS-CoV-2. The randomized, double-blind, placebo-controlled clinical trial of healthcare workers in the US and Canada found that for once weekly hydroxychloroquine prophylaxis, the hazard ratio for COVID-19 was 0.72 (95%CI 0.44 \u2013 1.16), and for twice-weekly it was 0.74 (95%CI 0.46 \u2013 1.19), as compared with placebo.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Rajasingham et al. (Oct 17, 2020). Hydroxychloroquine as Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers: A Randomized Trial. Clinical Infectious Diseases. <\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1571\">https:\/\/doi.org\/10.1093\/cid\/ciaa1571<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pre-exposure prophylaxis with hydroxychloroquine once or twice weekly did not significantly reduce COVID-19 or COVID-19-compatible illness among healthcare workers with ongoing exposure to people with SARS-CoV-2. The randomized, double-blind, placebo-controlled clinical trial of healthcare workers in the US and Canada found that for once weekly hydroxychloroquine prophylaxis, the hazard ratio for COVID-19 was 0.72 (95%CI&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/19\/hydroxychloroquine-as-pre-exposure-prophylaxis-for-covid-19-in-healthcare-workers-a-randomized-trial-2\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-1640","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1640"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1640\/revisions"}],"predecessor-version":[{"id":1641,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1640\/revisions\/1641"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1640"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}