{"id":1663,"date":"2020-10-20T09:37:18","date_gmt":"2020-10-20T16:37:18","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1663"},"modified":"2020-10-21T09:40:42","modified_gmt":"2020-10-21T16:40:42","slug":"effect-of-tocilizumab-vs-usual-care-in-adults-hospitalized-with-covid-19-and-moderate-or-severe-pneumonia","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/20\/effect-of-tocilizumab-vs-usual-care-in-adults-hospitalized-with-covid-19-and-moderate-or-severe-pneumonia\/","title":{"rendered":"Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia"},"content":{"rendered":"<ul>\n<li>A randomized, open-label trial of patients with COVID-19 and pneumonia who required oxygen support but were not admitted to ICU found no statistically significant difference in mortality over 28 days between those receiving the immunomodulator tocilizumab (TCZ) (n=63) and those receiving standard of care (n=67). At day 14, the proportion of patients with noninvasive ventilation, intubation or death was observed in 24% in the TCZ group vs 36% in the standard care group (posterior median HR=0.58; 90% Credibility Interval 0.33 to 1.00), suggesting a potential benefit. By day 28, there was no difference in death between the groups (aHR=0.92; 95%CI 0.33-2.53).<\/li>\n<\/ul>\n<p>Hermine et al. (Oct 20, 2020). Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia. JAMA Internal Medicine. <a href=\"https:\/\/doi.org\/10.1001\/jamainternmed.2020.6820\">https:\/\/doi.org\/10.1001\/jamainternmed.2020.6820<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A randomized, open-label trial of patients with COVID-19 and pneumonia who required oxygen support but were not admitted to ICU found no statistically significant difference in mortality over 28 days between those receiving the immunomodulator tocilizumab (TCZ) (n=63) and those receiving standard of care (n=67). At day 14, the proportion of patients with noninvasive ventilation,&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/20\/effect-of-tocilizumab-vs-usual-care-in-adults-hospitalized-with-covid-19-and-moderate-or-severe-pneumonia\/\">Read more<\/a><\/div>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-1663","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1663"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1663\/revisions"}],"predecessor-version":[{"id":1664,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1663\/revisions\/1664"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1663"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}