{"id":1689,"date":"2020-10-21T12:17:25","date_gmt":"2020-10-21T19:17:25","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=1689"},"modified":"2020-10-22T12:19:39","modified_gmt":"2020-10-22T19:19:39","slug":"the-effect-of-prior-acei-arb-treatment-on-covid-19-susceptibility-and-outcome-a-systematic-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/21\/the-effect-of-prior-acei-arb-treatment-on-covid-19-susceptibility-and-outcome-a-systematic-review-and-meta-analysis\/","title":{"rendered":"The Effect of Prior ACEI\/ARB Treatment on COVID-19 Susceptibility and Outcome: A Systematic Review and Meta-Analysis"},"content":{"rendered":"<p>A systematic review and meta-analysis (49 studies) reported no association between treatment with angiotensin-converting enzyme inhibitors (ACEI) and\/or angiotensin receptor blockers (ARB) and risk of SARS-CoV-2 infection (adjusted OR=1.00, 95%CI 0.94-1.05). The use of ACEI\/ARB was also not associated with the risk of mortality (aOR=0.87, 95%CI 0.66-1.04) and severe outcomes (aOR=0.95, 95%CI 0.73-1.24). These findings remain consistent in subgroup analyses stratified by populations and drug exposures and in other secondary outcomes.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><i>Xu et al. (Oct 20, 2020). The Effect of Prior ACEI\/ARB Treatment on COVID-19 Susceptibility and Outcome: A Systematic Review and Meta-Analysis. Clinical Infectious Diseases. <\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1592\">https:\/\/doi.org\/10.1093\/cid\/ciaa1592<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A systematic review and meta-analysis (49 studies) reported no association between treatment with angiotensin-converting enzyme inhibitors (ACEI) and\/or angiotensin receptor blockers (ARB) and risk of SARS-CoV-2 infection (adjusted OR=1.00, 95%CI 0.94-1.05). The use of ACEI\/ARB was also not associated with the risk of mortality (aOR=0.87, 95%CI 0.66-1.04) and severe outcomes (aOR=0.95, 95%CI 0.73-1.24). These findings&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/10\/21\/the-effect-of-prior-acei-arb-treatment-on-covid-19-susceptibility-and-outcome-a-systematic-review-and-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-1689","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=1689"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1689\/revisions"}],"predecessor-version":[{"id":1690,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/1689\/revisions\/1690"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=1689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=1689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=1689"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=1689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}